S8633
鞘磷酯酶 来源于金黄色葡萄球菌
buffered aqueous glycerol solution, 100-300 units/mg protein (Lowry)
别名:
鞘磷脂磷酸二酯酶, 鞘磷脂胆碱磷酸水解酶
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化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.32
MDL number:
Specific activity:
100-300 units/mg protein (Lowry)
form
buffered aqueous glycerol solution
specific activity
100-300 units/mg protein (Lowry)
storage temp.
2-8°C
Quality Level
Application
金黄色葡萄球菌鞘氨醇酶已用于：
- 二甲胺四环素诱导大鼠皮层神经毒性的研究
- 血清样品中的鞘磷脂浓度测定
- 增强鞘磷脂酶活性，研究 PARK9 介导的外泌体生物发生
Biochem/physiol Actions
启动形成基于鞘磷脂的第二信使。激活MAPK（丝裂原活化蛋白激酶）和SAPKs（应激活化蛋白激酶）；由鞘磷脂生成神经酰胺。
细菌鞘磷脂酶在中性 pH 下具有活性。用于体外细胞培养时，它会水解质膜外叶上的鞘磷脂，并产生脂溶性神经酰胺。鞘磷脂酶是鞘磷脂酶/神经酰胺途径中的关键酶，与几种神经退行性疾病的发病机制有关。
Physical form
溶于含0.25 M磷酸盐缓冲液的50%甘油，pH 7.5
Other Notes
在pH 7.4和37℃条件下，1个单位将每分钟水解1.0 μmol TNPAL-鞘磷脂。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
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