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S8326

Sigma-Aldrich

SKI 5C

≥98% (HPLC)

别名:

2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethyl ester-3-oxazolidinecarboxylic acid, SPHK1 Inhibitor 5C

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About This Item

经验公式（希尔记法）:
C26H45NO4
CAS号:
120005-55-2
分子量:
435.64
MDL编号:
MFCD18428021
UNSPSC代码:
12352202
PubChem化学物质编号:
329824601

质量水平

100

方案

≥98% (HPLC)

表单

oil

颜色

colorless to light brown

储存温度

2-8°C

SMILES字符串

CCCCCCCCCCCCCC#CC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C

InChI

1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1

InChI key

YGBSGZPIDCXNEH-QFIPXVFZSA-N

应用

SKI 5C was used to inhibit Sphingosine kinase 1 in SK-Hep1, HEK-293T cells.1

生化/生理作用

SKI 5C is a selective Sphingosine Kinase 1 (SPHK1) inhibitor.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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分析证书(COA)

Lot/Batch Number
110M4615V
0000024063
0000024062
110M4615

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Liver international : official journal of the International Association for the Study of the Liver, 32(2), 331-338 (2011-11-22)
Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine-1-phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene in tumorigenesis. However, little is known about the precise role of the SphK1/S1P pathway in human liver
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Cell reports, 34(12), 108896-108896 (2021-03-25)
Severe and often fatal opportunistic fungal infections arise frequently following mucosal damage caused by trauma or cytotoxic chemotherapy. Interaction of fungal pathogens with epithelial cells that comprise mucosae is a key early event associated with invasion, and, therefore, enhancing epithelial

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