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Merck
CN

S8071

Sigma-Aldrich

丹酚 A

≥98% (HPLC), solid

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别名:
(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(乙酰氧基)-2-(3-呋喃基)十二氢-6a,10b-二甲基-4,10-二氧代-2H-萘[2,1 -c]吡喃-7-羧酸甲酯
经验公式(希尔记法):
C23H28O8
CAS号:
分子量:
432.46
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

solid

药品控制

regulated under CDSA - not available from Sigma-Aldrich Canada

储存条件

protect from light

颜色

white

溶解性

DMSO: ≥10 mg/mL
ethanol: ~3 mg/mL

储存温度

−20°C

SMILES字符串

[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

InChI key

OBSYBRPAKCASQB-AGQYDFLVSA-N

基因信息

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应用

给予大鼠Salvinorin A来研究其对乳酸刺激的拉伸的影响。1

生化/生理作用

Salvinorin A是一种有效的无氮κ阿片类选择性受体激动剂。Salvinorin A分离自墨西哥鼠尾草。Salvinorin A在天然(Ki = 4.3 nm)和克隆的(Ki = 16 nm)κ -阿片受体上均表现出高亲和力。初步研究表明,Salvanorin A在精神药物中具有独特的化学性质并不与任何已知受体结合。

特点和优势

《受体分类和信号转导》手册的 阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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John Stogner et al.
The International journal on drug policy, 23(6), 512-521 (2012-04-17)
A plant with dissociative and psychoactive properties began to attract the attention of the media and United States policymakers following a well-publicized suicide in 2006 and reports that the plant served as a 'legal high' and substitute for cannabis. As
Justyna Piekielna et al.
Postepy biochemii, 58(4), 485-491 (2012-01-01)
Salvinorin A (SA) is the main active ingredient of Salvia divinorum, a naturally occurring hallucinogen plant from Mexico. Traditionally, herbal preparations obtained from Salvia were used by the Mazatec Indians for their divination rites and the treatment of gastrointestinal disorders.
Thomas E Prisinzano
Journal of medicinal chemistry, 56(9), 3435-3443 (2013-04-04)
The neoclerodane diterpene salvinorin A is the major active component of the hallucinogenic mint plant Salvia divinorum Epling and Játiva (Lamiaceae). Since the finding that salvinorin A exerts its potent psychotropic actions through the activation of opioid receptors, the site
Diansan Su et al.
Anesthesia and analgesia, 114(1), 200-204 (2011-11-15)
Cerebral hypoxia/ischemia during infant congenital heart surgery is not uncommon and may induce devastating neurologic disabilities persistent over the lifespan. Hypoxia/ischemia-induced cerebrovascular dysfunction is thought to be an important contributor to neurological damage. No pharmacological agents have been found to
Francesca Guida et al.
Molecular pain, 8, 60-60 (2012-08-24)
Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effects and the mode

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