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Merck
CN

S8071

丹酚 A

≥98% (HPLC), solid

别名:

(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(乙酰氧基)-2-(3-呋喃基)十二氢-6a,10b-二甲基-4,10-二氧代-2H-萘[2,1 -c]吡喃-7-羧酸甲酯

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关于此项目

经验公式(希尔记法):
C23H28O8
化学文摘社编号:
分子量:
432.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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InChI key

OBSYBRPAKCASQB-AGQYDFLVSA-N

SMILES string

[H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC

InChI

1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada; Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

storage condition

protect from light

color

white

solubility

DMSO: ≥10 mg/mL, ethanol: ~3 mg/mL

storage temp.

−20°C

Quality Level

Gene Information

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Application

给予大鼠Salvinorin A来研究其对乳酸刺激的拉伸的影响。1

Biochem/physiol Actions

Salvinorin A是一种无氮κ阿片类选择性受体激动剂。
Salvinorin A是一种有效的无氮κ阿片类选择性受体激动剂。Salvinorin A分离自墨西哥鼠尾草。Salvinorin A在天然(Ki = 4.3 nm)和克隆的(Ki = 16 nm)κ -阿片受体上均表现出高亲和力。初步研究表明,Salvanorin A在精神药物中具有独特的化学性质并不与任何已知受体结合。

Features and Benefits

《受体分类和信号转导》手册的 阿片类药物受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mohini Ranganathan et al.
Biological psychiatry, 72(10), 871-879 (2012-07-24)
Salvia divinorum (Salvia) is an increasingly popular recreational drug amongst adolescents and young adults. Its primary active ingredient, Salvinorin A (SA)-a highly selective agonist at the κ opiate receptor-is believed to be one of the most potent naturally occurring hallucinogens.
Ivo Moreno et al.
Bioanalysis, 5(6), 661-668 (2013-03-15)
The aim of this work was to develop and validate a method for the determination of Salvinorin A in human urine using microextraction by packed sorbent (MEPS) and GC-MS/MS. The technique uses a sample volume as low as 0.2 ml
Joanna Listos et al.
Pharmacological reports : PR, 63(6), 1305-1309 (2012-02-24)
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been historically used for divination and shamanism by the Mazatecs. Today, S. divinorum has become increasingly popular as a recreational drug for its
Eduardo R Butelman et al.
The Journal of pharmacology and experimental therapeutics, 341(3), 802-808 (2012-03-22)
Active blood-brain barrier mechanisms, such as the major efflux transporter P-glycoprotein (mdr1), modulate the in vivo/central nervous system (CNS) effects of many pharmacological agents, whether they are used for nonmedical reasons or in pharmacotherapy. The powerful, widely available hallucinogen salvinorin
Justyna Piekielna et al.
Postepy biochemii, 58(4), 485-491 (2012-01-01)
Salvinorin A (SA) is the main active ingredient of Salvia divinorum, a naturally occurring hallucinogen plant from Mexico. Traditionally, herbal preparations obtained from Salvia were used by the Mazatec Indians for their divination rites and the treatment of gastrointestinal disorders.

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