S8070
Anti-SUMO-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-GMP1, Anti-PIC1, Anti-SMT3C, Anti-SMT3H3, Anti-Sentrin-1, Anti-Small Ubiquitin-related Modifiier-1, Anti-UBL1
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IF, IP, WB
Citations:
22
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 14 kDa (unconjugated SUMO-1), antigen 41 kDa (SUMO-1-GST)
species reactivity
human
technique(s)
immunoprecipitation (IP): 10-20 μg using a nuclear extract of HeLa cells, indirect immunofluorescence: 4-8 μg/mL using human HeLa cells, microarray: suitable, western blot: 0.5-1 μg/mL using nuclear extract of HeLa cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
cow ... SUMO1(614967)
human ... SUMO1(7341)
mouse ... Sumo1(22218)
rat ... Sumo1(301442)
正在寻找类似产品? 访问 产品对比指南
General description
The SUMO-1 (small ubiquitin-like modifier 1) gene is mapped to human chromosome 2q33.1 and is highly conserved. The protein structure includes an α-helix core surrounded by four-stranded β-sheets.
Immunogen
synthetic peptide corresponding to amino acid 1-16 located at the N-terminus of human SUMO-1, conjugated to KLH. The sequence is identical in many species including mouse, rat, dog, bovine, and highly conserved (single amino acid substitution) in chicken and Xenopus SUMO-1. It is not found in human SUMO-2 and SUMO-3.
Application
Anti-SUMO-1 antibody produced in rabbit has been used in immunoblotting assay.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
SUMO (small ubiquitin-like modifier) proteins are associated with a number of cellular processes. SUMOylation mediated by SUMO1 is involved in nuclear transport mechanism, apoptosis, regulation of cyclin-dependent kinase 6 and protein stability. SUMO1 regulates tumor suppressor p53 protein, a transcription factor that is termed as the “guardian of the genome” plays a key role in the cell cycle events. Unlike ubiquitination which directs proteins for degradation, SUMOylation aims to alter the stability, localization and the function of the target protein.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.
Ke J, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 12203-12211 (2016)
Liberty François-Moutal et al.
Pain, 159(10), 2115-2127 (2018-05-31)
We previously reported that destruction of the small ubiquitin-like modifier (SUMO) modification site in the axonal collapsin response mediator protein 2 (CRMP2) was sufficient to selectively decrease trafficking of the voltage-gated sodium channel NaV1.7 and reverse neuropathic pain. Here, we
A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide?Protein Conjugates.
Drobecq H, et al.
Bioconjugate Chemistry, 27(6), 1540-1546 (2016)
Salmonella engages host microRNAs to modulate SUMOylation: a new arsenal for intracellular survival.
Verma S, et al.
Molecular and Cellular Biology (2015)
SUMOylation represses the transcriptional activity of the Unfolded Protein Response transducer ATF6.
Hou X, et al.
Biochemical and Biophysical Research Communications, 494(3), 446-451 (2017)
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持