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S7947

Stattic

Name: Stattic
Brand: SIGMA

≥98% (HPLC), STAT3 activation inhibitor, powder

别名:

6-硝基苯并[b] 噻吩-1,1-二氧化物, Stat 三种抑制化合物

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关于此项目

经验公式（希尔记法）:

C₈H₅NO₄S

化学文摘社编号:

19983-44-9

分子量:

211.19

UNSPSC Code:

12352200

PubChem Substance ID:

329824592

NACRES:

NA.77

MDL number:

MFCD00173799

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

Stattic, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >20 mg/mL

SMILES string

[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1

InChI

1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChI key

ZRRGOUHITGRLBA-UHFFFAOYSA-N

说明

Application

Stattic 用于抑制信号转导子和转录激活因子3（STAT3）的活性，适用各种细胞系和培养物中。

Stattic 用于研究人肺癌细胞中 Stat3 介导的细胞信号传导。⁵

Biochem/physiol Actions

Stattic 是一种不可逆的 STAT3 活化抑制剂。

Stattic（Stat3 三抑制化合物）改变 Stat3 的 SH2 结构域，间接抑制与磷肽结合。与其他磷酸肽类相比，它易于跨膜转运。² Stattic 诱导 ROS 形成增加，对心肌细胞线粒体功能产生负面影响，³并使鼻咽癌细胞对放化疗敏感。⁴

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma.

Yunbao Pan et al.

PloS one, 8(1), e54565-e54565 (2013-02-06)

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus-associated malignancy most common in East Asia, Africa and Alaska. Radiotherapy and cisplatin-based chemotherapy are the main treatment options. Unfortunately, disease response to concurrent chemoradiotherapy varies among patients with NPC, and many cases are

Proatherogenic stimuli induce HuR in atherosclerosis through MAPK/ErK pathway

Cheng M, et al.

American Journal of Translational Research, 11(4), 2317-2317 (2019)

IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis.

Nikolaos Sismanopoulos et al.

PloS one, 7(3), e33271-e33271 (2012-03-14)

Interleukin 9 (IL-9) has been implicated in mast cell-related inflammatory diseases, such as asthma, where vascular endothelial growth factor (VEGF) is involved. Here we report that IL-9 (10-20 ng/ml) induces gene expression and secretion of VEGF from human LAD2. IL-9

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全球贸易项目编号

货号	GTIN
S7947-25MG	04061833221433