产品名称
抗-SMC6 兔抗, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 126 kDa
species reactivity
human, rat (predicted), mouse (predicted)
technique(s)
western blot: 1:250-1:500 using whole cell extract of HEK293-T expressing SMC6
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SMC6(79677)
mouse ... Smc6(67241)
rat ... Smc6l1(313961)
Application
兔抗SMC6抗体可用于免疫印迹。
Biochem/physiol Actions
抗SMC6（也称为SMC6L1）特异性识别SMC6。
染色体蛋白6（SCM6）和SMC5的结构维持主要参与酵母和人类对DNA损伤的细胞反应。酵母SMC5/6复合物包含几种非SMC元素（NSE），包括甲磺酸甲酯敏感性蛋白21（MMS21），其磺酰化复合物的组分。SMC5/6复合物被募集到核酸酶诱导的双链断裂（DSBs）。此事件对于将人类SMC1/3内聚复合物募集到DSB至关重要。已知SCM6与乳头瘤病毒E2蛋白相互作用。拓扑异构酶IIα的有丝分裂畸变和异常分布与Smc5和Smc6的水平降低有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
染色体结构维持蛋白6（SCM6）属于染色体结构维持家族。至少有六个SMC家族成员以特定组合形成三个异二聚体。SCM6基因定位于人染色体2p24.2。在结构上，SCM6在N和C末端具有DNA结合结构域，一个长的卷曲螺旋结构域和一个铰链区。
Immunogen
对应于人SMC6第766-779个氨基酸的合成肽，通过N-末端的半胱氨酸残基与KLH发生偶联。该序列在小鼠中相差一个氨基酸，在大鼠中相差两个氨基酸。
Physical form
溶于含15 mM叠氮化钠的0.01 M磷酸盐缓冲盐水（pH 7.4）中。
Preparation Note
若需连续使用，可在2-8℃下保存最长一个月。若需延长储存时间，可将溶液分装并冷冻。不建议反复冻融或存放在“无霜”冰柜中。如果长期储存时出现轻微浑浊，请在使用前通过离心澄清溶液。如果在12小时内未使用，则应丢弃工作稀释样品。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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法规信息
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