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CN
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安全信息

S7796

Sigma-Aldrich

紫苏雷素 硫酸盐

≥580 μg/mg (USP)

别名:

O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->4)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1->6))-2-deoxy-L-streptamine sulfate (2:5) (salt)

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About This Item

经验公式（希尔记法）:
C19H37N5O7 · 2.5H2O4S
CAS号:
53179-09-2
分子量:
692.72
EC 号:
258-414-4
UNSPSC代码:
51281665
PubChem化学物质编号:
329824589
NACRES:
NA.85

表单

powder

浓度

≥580 μg/mg (USP)

颜色

white to off-white

抗生素抗菌谱

Gram-negative bacteria

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3OC(CN)=CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6OC(CN)=CC[C@H]6N)[C@@H]5O

InChI

1S/2C19H37N5O7.5H2O4S/c2*1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;5*1-5(2,3)4/h2*3,9-18,24-27H,4-7,20-23H2,1-2H3;5*(H2,1,2,3,4)/t2*9-,10+,11-,12+,13-,14-,15+,16-,17-,18-,19+;;;;;/m11...../s1

InChI key

CIKNYWFPGZCHDL-ZHFUJENKSA-N

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一般描述

Chemical structure: aminoglycoside

应用

Sisomicin is an aminoglycoside antibiotic isolated from Micromonopora inyoensis. It is effective against most strains of Klebsiellk spp., Escherichia coli, P. aeruginosa, Enterobacter and Proteus spp.. It is a potential treatment for conjunctiva . It is used in disk and tube dilution sensitivity test.

生化/生理作用

Sisomicin interferes with protein synthesis at the level of functional ribosome assembly. The mechanism is similar to that of gentamycin. Sisomicin closely resembles gentamicin but is more effective against Pseudomonas aeruginosa and indole-positive Proteus.

包装

250MG,1G,5G

储存及稳定性

Keep container tightly closed in a dry and well-ventilated place.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H312 + H332,H360

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000307901
0000307901
0000263602
0000203114
0000203122

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Stephen Hanessian et al.
Chemical communications (Cambridge, England), 46(12), 2013-2015 (2010-03-12)
Aminoglycoside 66-40C, an unprecedented 16-membered bis-azadiene macrocyclic natural product isolated from the Micromonospora producer of the antibiotic sisomicin, was synthesized following a biomimetic strategy which definitively established its origin as arising from a remarkably selective non-enzymatic macro-dimerization.
Gengrong Lin et al.
Antimicrobial agents and chemotherapy, 54(5), 2258-2261 (2010-02-11)
Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4
Clinical Pharmacology of Sisomicin
Victorio Rodriguez, Gerald P. Bodey, et al.
Antimicrobial Agents and Chemotherapy, 7, 182-195 (1975)
David Landman et al.
The Journal of antimicrobial chemotherapy, 66(2), 332-334 (2010-12-07)
Multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa have become a global problem, often leaving the polymyxins as therapeutic agents of last resort. ACHN-490, a next-generation aminoglycoside with activity against a broad range of Gram-positive and Gram-negative pathogens, was examined against clinical
D M Livermore et al.
The Journal of antimicrobial chemotherapy, 66(1), 48-53 (2010-11-17)
the emergence of carbapenemases in Enterobacteriaceae is driving a search for therapeutic alternatives. We tested ACHN-490, a sisomicin derivative that evades all plasmid-mediated aminoglycoside-modifying enzymes, against 82 carbapenem-resistant Enterobacteriaceae isolates. Comparators included internationally and locally available aminoglycosides. Methods The isolates
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