推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~75 kDa
种属反应性
mouse, rat, human
浓度
~1 mg/mL
技术
indirect immunofluorescence: 5-10 μg/mL using human HeLa cells
western blot (chemiluminescent): 1-2 μg/mL using whole extracts of mouse NIH-3T3 and rat ROS cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SEC23A(10484)
mouse ... Sec23a(20334)
rat ... Sec23a(58817)
一般描述
Sec23 has two isoforms, Sec23A and Sec23B. Sec23A is mainly found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles.
Sec23A (Sec23 homolog A) is a human Sec23 paralog, that is a GTPase-activating protein. It is a fundamental constituent of the coat protein II complex. It is located on human chromosome 14q21.
免疫原
synthetic peptide corresponding to amino acid residues 1-18 of human Sec23A with C-terminal added cysteine conjugated to KLH. The corresponding sequence is identical in rat and mouse Sec23A and differs by one amino acid in human and mouse Sec23B.
应用
Anti-Sec23 antibody has been used in immunoblotting, in western blot analysis, immunofluorescence.
生化/生理作用
Sec23A (Sec23 homolog A) plays an important role in protein trafficking between the endoplasmic reticulum and Golgi apparatus. It also participates in anti-tumorigenesis. Suppressing the expression of Sec23A induces multiplication, migration, and invasion of CRC cells (colorectal cancer). Mutation in SEC23A gene results in cranio-lenticulo-sutural dysplasia.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport
Cutrona M B, et al.
Traffic, 14(6), 691-708 (2013)
Inherited hematological disorders due to defects in coat protein (COP)II complex
Russo R, et al.
American Journal of Hematology, 88(2), 135-140 (2013)
MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression
Li C, et al.
BMC Cancer, 16 (2016)
CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells
Garcia I A, et al.
Journal of Cell Science, 130(24), 4155-4167 (2017)
Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction
Leonhardt RM, et al.
The Journal of Biological Chemistry, 285(21), 16166-16183 (2010)
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