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安全信息

S7632

Sigma-Aldrich

N-Succinyl-Ala-Ala-Val-Ala p-nitroanilide

protease substrate

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About This Item

经验公式（希尔记法）:
C24H34N6O9
CAS号:
108322-03-8
分子量:
550.56
MDL编号:
MFCD00133618
UNSPSC代码:
12352204
PubChem化学物质编号:
24899748
NACRES:
NA.32

质量水平

200

方案

≥98% (TLC)

表单

powder

溶解性

DMF: 10 mg/mL, clear, colorless

UniProt登记号

P57774

储存温度

−20°C

SMILES字符串

CC(C)C(NC(=O)C(C)NC(=O)C(C)NC(=O)CCC(O)=O)C(=O)NC(C)C(=O)Nc1ccc(cc1)N(=O)=O

InChI

1S/C24H34N6O9/c1-12(2)20(24(37)27-14(4)22(35)28-16-6-8-17(9-7-16)30(38)39)29-23(36)15(5)26-21(34)13(3)25-18(31)10-11-19(32)33/h6-9,12-15,20H,10-11H2,1-5H3,(H,25,31)(H,26,34)(H,27,37)(H,28,35)(H,29,36)(H,32,33)

InChI key

IYHHIHIBYVIDMJ-UHFFFAOYSA-N

基因信息

mouse ... Npy(109648)

一般描述

N-Succinyl-Ala-Ala-Val-Ala p-nitroanilide is a chromogenic and a synthetic peptide substrate for proteases, elastase and subtilisin.

应用

N-Succinyl-Ala-Ala-Val-Ala p-nitroanilide has been used as a synthetic peptide substrate for:
  • Bacillus pumilus alkaline protease (DHAP)
  • mesophilic subtilisin Carlsberg (sC) to assess the hydrolytic activity of wild-type and mutant sC
  • Pseudoalteromonas arctica cold-active protease (Pro21717)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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分析证书(COA)

Lot/Batch Number
BCCH3495
BCCG0918
BCCC8335
BCBV9789
BCBT6616

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Naoki Fuchita et al.
Biochimica et biophysica acta, 1824(4), 620-626 (2012-02-14)
A comparison of the primary structures among psychrophilic, mesophilic, and thermophilic subtilases revealed that the turn between the β8 and β9 strands (β8-β9 turn, BPN' numbering) of psychrophilic subtilases are more flexible than those of their mesophilic and thermophilic counterparts.
Subtilisin enzymes: Practical protein engineering, 379 (2013)
Ha Ju Park et al.
PloS one, 13(2), e0191740-e0191740 (2018-02-22)
Enzymes isolated from organisms found in cold habitats generally exhibit higher catalytic activity at low temperatures than their mesophilic homologs and are therefore known as cold-active enzymes. Cold-active proteases are very useful in a variety of biotechnological applications, particularly as
William R Swindell et al.
The Journal of investigative dermatology, 140(3), 602-614 (2019-08-30)
Zingerone (Z) is a phenolic alkanone derived from natural sources with anti-inflammatory and antioxidant effects. Acetyl zingerone (AZ) is a recently designed molecule that shares structural features with Z but is expected to have improved stability and antioxidant function. This
Min-Yuan Wan et al.
Applied biochemistry and biotechnology, 159(2), 394-403 (2009-01-10)
An alkaline protease (DHAP) from Bacillus pumilus has shown great potential in hide dehairing. To get better insights on its catalytic properties for application, the substrate specificity and thermostability were investigated using five natural proteins and nine synthetic peptides. The
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