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质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
DMSO: 10 mg/mL, clear
储存温度
room temp
SMILES字符串
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
InChI
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key
BTGNGJJLZOIYID-UHFFFAOYSA-N
应用
西维来司钠水合物可用于抑制人中性粒细胞弹性蛋白酶介导的细胞信号传导。
生化/生理作用
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂 (IC50 = 44 nM，Ki = 0.2 μM)。它也抑制从兔、大鼠、仓鼠和小鼠中获得的白细胞弹性蛋白酶（IC50 = 19 至 49 nM）。但即使在 100 μM 时，它也不抑制胰蛋白酶、凝血酶、纤溶酶、血浆激肽释放酶、胰激肽释放酶、糜蛋白酶和组织蛋白酶 G。在体内研究中，它抑制仓鼠肺出血（ID50=82 μMg/kg）气管内给药和静脉给药增加豚鼠皮肤毛细血管通透性 (ID50 = 9.6 mg/kg)，均由人中性粒细胞弹性蛋白酶诱导。
西维来司钠是一种竞争性人中性粒细胞弹性蛋白酶 (HNE) 抑制剂。
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Naoya Fujino et al.
Experimental lung research, 38(1), 28-36 (2011-12-14)
Excess production of neutrophil elastase contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the role of neutrophil elastase in the repair process following ALI/ARDS is not well understood. The objective of this
Jessica Fox et al.
International journal of radiation oncology, biology, physics, 85(1), 215-222 (2012-08-30)
We previously reported increased numbers of neutrophils to be associated with the development of the radiation-induced lung responses of alveolitis (pneumonitis) and fibrosis in mice. In the present study we investigated whether CXC receptor 1 and 2 antagonism with DF2156A
Kasturi Ganguly et al.
Frontiers in immunology, 13, 930449-930449 (2022-07-26)
Surfactant protein D (SP-D), a pattern recognition molecule, is emerging as a potent anti-tumoural innate immune defense molecule in a range of cancers. Previously, SP-D expression was found to be significantly downregulated at the malignant sites of human prostate adenocarcinoma
Kenji Okada et al.
The Journal of thoracic and cardiovascular surgery, 144(1), 139-145 (2011-10-01)
Recent advancements in total aortic arch replacement achieved by our approach were presented. From January 2002 to December 2010, 321 consecutive patients (mean age 69.8 ± 13.3 years) underwent total arch replacement through a median sternotomy at our institute. Aortic
Seigo Miyoshi et al.
Drug design, development and therapy, 7, 305-316 (2013-04-19)
Neutrophil elastase plays a crucial role in the development of acute lung injury (ALI) in patients with systemic inflammatory response syndrome (SIRS). The clinical efficacy of the neutrophil elastase inhibitor, sivelestat, for patients with ALI associated with SIRS has not
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