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主要文件

安全信息

S6942

Sigma-Aldrich

Staurosporine

from Streptomyces sp., >98% (HPLC), solution, protein kinase inhibitor

别名:

Antibiotic AM-2282

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About This Item

EC 号:
200-664-3
MDL编号:
MFCD04041131
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

Staurosporine 溶液 来源于链霉菌 属, Ready Made Solution, 1 mM in DMSO (100 μg/214 μL), 0.2 μm filtered

质量水平

300

无菌性

0.2 μm filtered

方案

>98% (HPLC)

浓度

1 mM in DMSO (100 μg/214 μL)

技术

cell culture | mammalian: suitable

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits

运输

wet ice

储存温度

−20°C

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一般描述

Chemical structure: indol derivative

应用

Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4

生化/生理作用

Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000209974
0000209974
0000202666
0000143044
0000128625

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What concentration of Staurosporin is used for the release of microparticles from apoptotic cells?

    Staurosporin can induce apopotosis in Jurkat cells (106/ml) at 1 ug/ml following a 1-2 hour incubation at 37°C. For the release of microparticles from apoptotic Jurkat cells, use staurosporin at 1 uM for 107 cells/ml. Please see the reference below for further details. Apoptosis 15(5):586, 2010.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Yu-Jung Lee et al.
American journal of physiology. Renal physiology, 292(1), F340-F350 (2006-08-10)
Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two
Suainibhe Kelly et al.
Nanoscale, 13(41), 17615-17628 (2021-10-19)
The use of nanomaterials as therapeutic delivery vehicles requires their careful pre-clinical evaluation. Of particular importance in this regard is measurement of cellular toxicity, ideally assessing multiple parameters in parallel from various relevant subcellular organelles. In recent years it has
Marije B Overdijk et al.
Molecular cancer therapeutics, 19(10), 2126-2138 (2020-08-28)
Higher-order death receptor 5 (DR5) clustering can induce tumor cell death; however, therapeutic compounds targeting DR5 have achieved limited clinical efficacy. We describe HexaBody-DR5/DR5, an equimolar mixture of two DR5-specific IgG1 antibodies with an Fc-domain mutation that augments antibody hexamerization
Dale W Hailey et al.
Cell, 141(4), 656-667 (2010-05-19)
Starvation-induced autophagosomes engulf cytosol and/or organelles and deliver them to lysosomes for degradation, thereby resupplying depleted nutrients. Despite advances in understanding the molecular basis of this process, the membrane origin of autophagosomes remains unclear. Here, we demonstrate that, in starved
Maren de Vries et al.
Journal of virology (2021-02-25)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus Disease 2019 (COVID-19). There is a dire need for novel effective antivirals to treat COVID-19, as the only approved direct-acting antiviral to date is remdesivir, targeting the
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