S6626
毒毛旋花子苷元
cardiotonic steroid
别名:
3β,5,14-三羟基-19-氧-5β,20(22)-强心苷, ;毒毛旋花苷配基, K-毒毛旋花子甙元, 毒毛旋花子甙元, 毒毛旋花子苷K, 毒毛旋花子苷元, 毒毛旋花甙元, 羊角拗定, 羊角拗甾醇
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经验公式（希尔记法）:
C23H32O6
化学文摘社编号:
分子量:
404.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-626-6
MDL number:
产品名称
毒毛旋花子苷元,
InChI
1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3
InChI key
ODJLBQGVINUMMR-UHFFFAOYSA-N
SMILES string
C[C@@]12[C@@](CC[C@@H]2C(CO3)=CC3=O)(O)[C@]4([H])CC[C@]5(O)C[C@@H](O)CC[C@]5(C([H])=O)[C@@]4([H])CC1
storage temp.
−20°C
Quality Level
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相关类别
Application
毒毛旋花子甙元可用于合成乙酰毒毛旋花子甙元，已研究其对狗隐静脉神经递质释放的影响。3
Biochem/physiol Actions
毒毛旋花子甙元(Strophanthidin)是一种强心苷，可提高心肌细胞中的Na+/K+-ATP酶活性。1在兔肾皮质切片中，它可降低钾含量，提高钠含量。2
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Julio Altamirano et al.
The Journal of physiology, 575(Pt 3), 845-854 (2006-07-11)
Glycoside-induced cardiac inotropy has traditionally been attributed to direct Na(+)-K(+)-ATPase inhibition, causing increased intracellular [Na(+)] and consequent Ca(2+) gain via the Na(+)-Ca(2+) exchanger (NCX). However, recent studies suggested alternative mechanisms of glycoside-induced inotropy: (1) direct activation of sarcoplasmic reticulum Ca(2+)
Effects of sodium pump activity on spontaneous firing in neurons of the rat suprachiasmatic nucleus.
Yi-Chi Wang et al.
Journal of neurophysiology, 96(1), 109-118 (2006-02-10)
Cell-attached and whole cell recording techniques were used to study the effects of electrogenic sodium pump on the excitability of rat suprachiasmatic nucleus (SCN) neurons. Blocking the sodium pump with the cardiac steroid strophanthidin or zero K+ increased the spontaneous
L W Woods et al.
Veterinary pathology, 41(3), 215-220 (2004-05-11)
Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding
Niaz Ahmad et al.
Kidney international, 66(1), 77-90 (2004-06-18)
Tissue damage at the time of organ transplantation has a negative impact on the subsequent success of the procedure, both in the immediate and longer term. Hypothermia is the principal element used to prolong organ viability ex vivo, but paradoxically
Sara Arganda et al.
Nature neuroscience, 10(11), 1467-1473 (2007-10-02)
Pump activity is a homeostatic mechanism that maintains ionic gradients. Here we examined whether the slow reduction in excitability induced by sodium-pump activity that has been seen in many neuronal types is also involved in neuronal coding. We took intracellular
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