所有图片(1)
About This Item
经验公式（希尔记法）:
C40H53N5O10
CAS号:
分子量:
763.88
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥90% (HPLC)
表单
powder
溶解性
0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
CC(C)CC(NC(=O)CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)
InChI key
UVFAEQZFLBGVRM-UHFFFAOYSA-N
Amino Acid Sequence
N-Suc-Leu-Leu-Val-Tyr-7-AMC
应用
用N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素测定水稻Jurkat细胞裂解液6和粗细胞裂解液中蛋白酶体类糜蛋白酶活性。7
生化/生理作用
在存在胰凝乳蛋白酶样酶活性的情况下，荧光团，7-氨基-4-甲基香豆素是从N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素中释放的。所获得的荧光可作为酶活性的量度。6
包装
无底玻璃瓶。内含物在插入的融合锥体内。
底物
用作胰凝乳蛋白酶样酶的荧光底物，例如组织蛋白酶B和钙蛋白酶，其与程序性细胞死亡有关。
O Ullrich et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(11), 6223-6228 (1999-05-26)
The 20S proteasome has been shown to be largely responsible for the degradation of oxidatively modified proteins in the cytoplasm. Nuclear proteins are also subject to oxidation, and the nucleus of mammalian cells contains proteasome. In human beings, tumor cells
S Glockzin et al.
The Journal of biological chemistry, 274(28), 19581-19586 (1999-07-03)
The ubiquitin/proteasome pathway mediates the degradation of many short-lived proteins that are critically involved in the regulation of cell proliferation and cell death, including the tumor suppressor protein p53. Accumulation of p53 and induction of apoptosis in RAW 264.7 macrophages
Madeline R Scott et al.
Molecular psychiatry, 25(4), 776-790 (2019-01-27)
Protein homeostasis is an emerging component of schizophrenia (SZ) pathophysiology. Proteomic alterations in SZ are well-documented and changes in transcript expression are frequently not associated with changes in protein expression in SZ brain. The underlying mechanism driving these changes remains
M Kroll et al.
Chemistry & biology, 6(10), 689-698 (1999-10-06)
The fungal epipolythiodioxopiperazine metabolite gliotoxin has a variety of toxic effects such as suppression of antigen processing, induction of macrophagocytic apoptosis and inhibition of transcription factor NF-kappaB activation. How gliotoxin acts remains poorly understood except that the molecule's characteristic disulfide
Turnover of oxidatively damaged nuclear proteins in BV-2 microglial cells is linked to their activation state by poly-ADP-ribose polymerase.
O Ullrich et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(8), 1460-1462 (2001-06-02)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门