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About This Item
经验公式（希尔记法）:
C40H53N5O10
CAS号:
分子量:
763.88
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥90% (HPLC)
表单
powder
溶解性
0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
CC(C)CC(NC(=O)CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
InChI
1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)
InChI key
UVFAEQZFLBGVRM-UHFFFAOYSA-N
Amino Acid Sequence
N-Suc-Leu-Leu-Val-Tyr-7-AMC
应用
用N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素测定水稻Jurkat细胞裂解液6和粗细胞裂解液中蛋白酶体类糜蛋白酶活性。7
生化/生理作用
在存在胰凝乳蛋白酶样酶活性的情况下，荧光团，7-氨基-4-甲基香豆素是从N-琥珀酰-亮氨酸-缬氨酸-酪氨酸-7-氨基-4-甲基香豆素中释放的。所获得的荧光可作为酶活性的量度。6
包装
无底玻璃瓶。内含物在插入的融合锥体内。
底物
用作胰凝乳蛋白酶样酶的荧光底物，例如组织蛋白酶B和钙蛋白酶，其与程序性细胞死亡有关。
S Glockzin et al.
The Journal of biological chemistry, 274(28), 19581-19586 (1999-07-03)
The ubiquitin/proteasome pathway mediates the degradation of many short-lived proteins that are critically involved in the regulation of cell proliferation and cell death, including the tumor suppressor protein p53. Accumulation of p53 and induction of apoptosis in RAW 264.7 macrophages
O Ullrich et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(11), 6223-6228 (1999-05-26)
The 20S proteasome has been shown to be largely responsible for the degradation of oxidatively modified proteins in the cytoplasm. Nuclear proteins are also subject to oxidation, and the nucleus of mammalian cells contains proteasome. In human beings, tumor cells
T Reinheckel et al.
The Biochemical journal, 335 ( Pt 3), 637-642 (1998-10-31)
Oxidatively modified ferritin is selectively recognized and degraded by the 20S proteasome. Concentrations of hydrogen peroxide (H2O2) higher than 10 micromol/mg of protein are able to prevent proteolytic degradation. Exposure of the protease to high amounts of oxidants (H2O2, peroxynitrite
Izaltina Silva-Jardim et al.
Acta tropica, 91(2), 121-130 (2004-07-06)
Proteasomes are multisubunit proteases that exist universally among eukaryotes. They have multiple proteolytic activities and are believed to have important roles in regulating cell cycle, selective intracellular proteolysis, and antigen presentation. Here we have partially purified Leishmania chagasi proteasome. The
Turnover of oxidatively damaged nuclear proteins in BV-2 microglial cells is linked to their activation state by poly-ADP-ribose polymerase.
O Ullrich et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(8), 1460-1462 (2001-06-02)
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DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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