跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

S6451

Sigma-Aldrich

SCH-442416

≥98% (HPLC)

别名:

2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo [4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; 5-amino-7-(3-(4-methoxyphenyl)propyl)-2-(2 furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine; 5-Amino-7-[3-(4-methoxy)phenylpropyl]-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C20H19N7O2
CAS号:
316173-57-6
分子量:
389.41
MDL编号:
MFCD08703126
UNSPSC代码:
12352200
PubChem化学物质编号:
329824564
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

light tan to tan

溶解性

DMSO: ≥20 mg/mL

储存温度

2-8°C

SMILES字符串

COc1ccc(CCCn2ncc3c2nc(N)n4nc(nc34)-c5ccco5)cc1

InChI

1S/C20H19N7O2/c1-28-14-8-6-13(7-9-14)4-2-10-26-18-15(12-22-26)19-23-17(16-5-3-11-29-16)25-27(19)20(21)24-18/h3,5-9,11-12H,2,4,10H2,1H3,(H2,21,24)

InChI key

AEULVFLPCJOBCE-UHFFFAOYSA-N

应用

SCH-442416 has been used:
  • as a selective adenosine A2A antagonist to study its effects on cyclic adenosine monophosphate (cAMP) production in T/C-28a2 chondrocytes or hFOB 1.19 osteoblasts 
  • as a presynaptic A2A receptor antagonists to study its effects on receptor blockade on δ9-Tetrahydrocannabinol (THC) self-administration in squirrel monkeys
  • as a presynaptic A2A receptor antagonists to study its effects on cocaine-induced locomotion and cocaine-seeking in mice

生化/生理作用

SCH-442416 potent and selective Adenosine A2a antagonist. SCH-442416 is >10,000-fold selective for A2a compared to other adensosine receptors.

特点和优势

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
021M4623V
0000114839
0000114840
0000060502
0000012831

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Fabrizio Vincenzi et al.
PloS one, 8(5), e65561-e65561 (2013-06-07)
Adenosine receptors (ARs) have an important role in the regulation of inflammation and their activation is involved in the inhibition of pro-inflammatory cytokine release. The effects of pulsed electromagnetic fields (PEMFs) on inflammation have been reported and we have demonstrated
Mallikarjunarao Ganesana et al.
PloS one, 13(5), e0196932-e0196932 (2018-05-26)
Adenosine is an important neuromodulator in the central nervous system, and tissue adenosine levels increase during ischemic events, attenuating excitotoxic neuronal injury. Recently, our lab developed an electrochemical fast-scan cyclic voltammetry (FSCV) method that identified rapid, spontaneous changes in adenosine
Takahiro Matsuya et al.
Journal of pharmacological sciences, 103(3), 329-332 (2007-03-08)
In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A(2A) antagonist SCH-58261, but not the A(1)-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or
Effects of adenosine A 2A receptor antagonists on cocaine-induced locomotion and cocaine seeking
Haynes N S, et al.
Psychopharmacology, 236(2), 699-708 (2019)
Xiaohan Xu et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(4), 353-364 (2017-01-12)
Neutrophil chemotaxis plays an essential role in recruiting neutrophils to sites of inflammation. Neutrophil chemotaxis is suppressed both after exposure to lipopolysaccharide (LPS) in vitro and during clinical and experimental endotoxemia, leading to serious consequences. Adenosine (ADO) is a potent
查看所有相关文献

商品

Adenosine Receptors

We offers many products related to adenosine receptors for your research needs.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门