跳转至内容
Merck
CN

S5947

Anti-Sirt7 兔抗

affinity isolated antibody, buffered aqueous solution

别名:

Anti-SIR2L7, Anti-Sir2-related protein type 7, Anti-Sirtuin (silent mating type information regulation 2 homolog) 7

登录 查看组织和合同定价。

选择尺寸

关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD07784768

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

Anti-Sirt7 兔抗, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~45 kDa

species reactivity

mouse (predicted), human

technique(s)

immunoprecipitation (IP): 2-4 μg using extracts of HEK-293T cells expressing human Sirt7
indirect immunofluorescence: 2-4 μg/mL using human HEK-293T cells
western blot: 1-2 μg/mL using whole extracts of HEK-293T cells expressing human Sirt7

UniProt accession no.

Q9NRC8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... SIRT7(51547)
mouse ... Sirt7(209011)

Physical form

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

Application

Anti-Sirt7 antibody produced in rabbit has been used in western blotting analysis and immunofluorescence detection.

Biochem/physiol Actions

Sirt7 (sirtuin 7) is extensively found in protein associated with active rRNA genes (rDNA), in the nucleolus. It interacts with RNA polymerase I (Pol I) and histones. Overexpression of Sirt7 increases Pol I-mediated transcription, whereas knockdown of Sirt7 or inhibition of its catalytic activity results in decreased association of Pol I with rDNA and reduces Pol I transcription. Depletion of Sirt7 stops cell proliferation and triggers apoptosis. High levels of Sirt7 expression are associated with breast cancer.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase (Sir2) is one of the silent information regulator genes in yeast. It belongs to a family of proteins, that is found in organisms ranging from bacteria to complex eukaryotes. Proteins of this family share a core domain showing 25-60% sequence identity. The mammalian Sir2 gene family is comprised of seven members which are designated as Sirt1-7.

Immunogen

synthetic peptide corresponding to amino acids 35-51 of human Sirt7, conjugated to KLH via a C-terminal cysteine residue. The sequence is identical in mouse.

未找到合适的产品？  

试试我们的产品选型工具.

存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000100142
0000089047
078M4826V
21180214
073M4787

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
Brachmann CB, et al.
Genes & Development, 9(23), 2888-2902 (1995)
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
Grob A, et al.
Journal of Cell Science, 122(4), 489-498 (2009)
Altered sirtuin expression is associated with node-positive breast cancer
Ashraf N, et al.
British Journal of Cancer, 95(8), 1056-1056 (2006)
The human silent information regulator (Sir) 2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
Schwer B, et al.
The Journal of Cell Biology, 158(4), 647-657 (2002)
Shashi Kiran et al.
The FEBS journal, 280(14), 3451-3466 (2013-05-18)
Sirtuins belong to a class of NAD-dependent deacetylases, and include seven distinct isoforms, of which SIRT7 is the least studied member. In the present study, the subcellular expression of SIRT7 in primary fibroblasts undergoing senescence was evaluated by immunocytochemistry and
查看所有相关文献

相关内容

Data Sheet - S5947

Instructions

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持