质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
yellow
溶解性
DMSO: ≥20 mg/mL
储存温度
2-8°C
SMILES字符串
CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13
InChI
1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22)
InChI key
CTDCVGDSVHUYMA-UHFFFAOYSA-N
应用
SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies.
生化/生理作用
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Aquatic Acute 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Andrea Funke et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 22(9), 3170-3181 (2016-01-26)
The interaction of phenyl-substituted indolo[3,2-b]quinolines with DNA G-quadruplexes of different topology were studied by using a combination of spectroscopic and calorimetric methodologies. N5-Methylated indoloquinoline derivatives ((Me) PIQ) with an aminoalkyl side chain exhibit high affinities for the parallel-stranded MYC quadruplex
Cindy K Miranti et al.
Oncotarget, 11(19), 1758-1776 (2020-06-02)
The androgen receptor (AR) is a major driver of prostate cancer development and progression. Men who develop advanced prostate cancer often have long-term cancer control when treated with androgen-deprivation therapies (ADT). Still, their disease inevitably becomes resistant to ADT and
Mary E Gagou et al.
Oncotarget, 5(22), 11381-11398 (2014-11-02)
Unwinding duplex DNA is a critical processing step during replication, repair and transcription. Pif1 are highly conserved non-processive 5'->3' DNA helicases with well-established roles in maintenance of yeast genome stability. However, the function of the sole member of Pif1 family
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