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安全信息

S5569

Sigma-Aldrich

Anti-Superoxide Dismutase (MnSOD) (KC-19) antibody produced in rabbit

enhanced validation

IgG fraction of antiserum, buffered aqueous solution

别名:

Anti-IPO-B, Anti-Indophenoloxidase B, Anti-MNSOD, Anti-Manganese Dependent SOD, Anti-Manganese Superoxide Dismutase 2, Anti-Mitochodrial SOD, Anti-Mn-SOD, Anti-SOD2, Anti-Superoxide Dismutase 2

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选择尺寸

10 G
CN¥383.71
25 G
CN¥509.14
100 G
CN¥1,768.94

CN¥383.71

国内现货，预计发货时间April 10, 2025详情

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选择尺寸

变更视图
10 G
CN¥383.71
25 G
CN¥509.14
100 G
CN¥1,768.94

About This Item

MDL编号:
MFCD06798546
UNSPSC代码:
12352203
NACRES:
NA.41

CN¥383.71

国内现货，预计发货时间April 10, 2025详情

生物来源

rabbit

偶联物

unconjugated

抗体形式

IgG fraction of antiserum

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~24 kDa

种属反应性

rat, human

增强验证

independent
Learn more about Antibody Enhanced Validation

技术

indirect immunofluorescence: 1:250-1:500 using methanol-acetone-fixed rat NRK cells
western blot: 1:1,000-1:2,000 using whole extract of rat brain and a chemiluminescent detection reagent
western blot: 1:2,000-1:4,000 using human HeLa mitochondria extract and a chemiluminescent detection reagent

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application(s)

pharmaceutical, sterility testing

application(s)

pharmaceutical
sterility testing

application(s)

pharmaceutical
sterility testing

application(s)

pharmaceutical
sterility testing

pore size

0.2 μm pore size

pore size

0.45 μm pore size

pore size

0.45 μm pore size

pore size

0.45 μm pore size

packaging

pkg of 25 units

packaging

pkg of 10 blisters per box, Single packed

packaging

pkg of 10 blisters per box, Single packed

packaging

pkg of 10 blisters in 2 bags of 5 blisters per box, Double packed

material

PTFE (hydrophobic membrane filter), stainless steel (for needle), PVC device

material

Nylon 66 adapter (for needle), PVC tubing (double lumen), mixed cellulose esters (MCE) membrane, plain filter, stainless steel (for needle), styrene-acrylonitrile (SAN) (for canister)

material

Nylon 66 adapter (for needle), PVC tubing (double lumen), PVDF membrane, plain filter, stainless steel (for needle), styrene-acrylonitrile (SAN) (for canister)

material

Nylon 66 adapter (for needle), PVC tubing (double lumen), PVDF membrane, plain filter, stainless steel (for needle), styrene-acrylonitrile (SAN) (for canister)

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

一般描述

Manganese superoxide dismutase (MnSOD) protein is a homotetrameric SOD. This protein is composed of four subunits, each containing one Mn2+. MnSOD enzyme is synthesized in the cytosol and is modified for its transport into the mitochondria where it resides in the matrix.
The SOD2 (superoxide dismutase 2) gene is mapped to human chromosome 6q25.3. The encoded protein functions as a tetramer and is localized to mitochondria.

特异性

Anti-Superoxide Dismutase (MnSOD) (KC-19) recognizes human and rat Superoxide Dismutase (MnSOD).

免疫原

synthetic peptide corresponding to amino acid residues 202-220 of human superoxide dismutase (MnSOD), conjugated to KLH. The corresponding sequence is identical in apes and monkeys, differs by one amino acid in mouse and horse, by two amino acids in cow, and by four amino acids in rat.

应用

Anti-Superoxide Dismutase (MnSOD) (KC-19) antibody produced in rabbit may be used in immunoblotting[1] and indirect immunofluorescence.

生化/生理作用

Manganese superoxide dismutase (MnSOD) is essential for the survival of aerobic life. This protein is inducible by tumor necrosis factor (TNF) and protects cells from TNF-mediated apoptosis. MnSOD is proposed to function as a tumor suppressor by modulating the activity of redox-sensitive transcription factors and specific signal mediators. Overexpression of the MnSOD gene protects neurons from N-methyl-D-aspartate receptor (NMDA) and nitric oxide-induced neurotoxicity. A decline in the MnSOD activity occurs in aging, progeria, cancer, asthma and transplant rejection.
Superoxide Dismutase 2 (SOD2) is an antioxidant enzyme and catalyzes the conversion of superoxide to hydrogen peroxide and molecular oxygen. The enzyme offers protection against oxidative damage induced by reactive oxygen species and also is radioprotective. The gene is associated with the metastasis and invasion process of salivary adenoid cystic carcinoma. Manganese SOD is involved in detoxification.

外形

Solution in phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000138769
0000131573
064K4795

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S K Manna et al.
The Journal of biological chemistry, 273(21), 13245-13254 (1998-05-28)
Several recently identified intracellular proteins associate with the tumor necrosis factor (TNF) receptor and activate nuclear transcription factor (NF)-kappaB, c-Jun kinase, and apoptosis. However, the mechanism is not understood. In the present report, we investigated the role of reactive oxygen
L A Macmillan-Crow et al.
Free radical research, 34(4), 325-336 (2001-05-01)
Manganese superoxide dismutase (MnSOD) is essential for life as dramatically illustrated by the neonatal lethality of mice that are deficient in MnSOD. In addition, mice expressing only 50% of the normal compliment of MnSOD demonstrate increased susceptibility to oxidative stress
Demet Candas et al.
Antioxidants & redox signaling, 20(10), 1599-1617 (2013-04-16)
The mitochondrial antioxidant manganese superoxide dismutase (MnSOD) is encoded by genomic DNA and its dismutase function is fully activated in the mitochondria to detoxify free radical O2(•-) generated by mitochondrial respiration. Accumulating evidence shows an extensive communication between the mitochondria
Sumitra Miriyala et al.
Biochimica et biophysica acta, 1822(5), 794-814 (2011-12-27)
Increased understanding of the role of mitochondria under physiological and pathological conditions parallels increased exploration of synthetic and natural compounds able to mimic MnSOD - endogenous mitochondrial antioxidant defense essential for the existence of virtually all aerobic organisms from bacteria
Two functional variants of the superoxide dismutase genes in Finnish families with asthma.
Kinnula V L, et al.
Thorax, 59(2), 116-119 (2004)
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