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一般描述
SRC proto-oncogene, non-receptor tyrosine kinase (SRC) belongs to the family of non-receptor tyrosine kinases. It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. The gene encoding this protein is localized on human chromosome 20q11.23.
应用
Human Src has been used to study the kinetics of Src entrapped in a series of different sol-gel derived materials.
生化/生理作用
SRC proto-oncogene, non-receptor tyrosine kinase (SRC) phosphorylates membrane proteins and nucleoproteins and activates various intracellular signaling cascades. It has been associated with a number of human malignancies and cancers.
单位定义
One unit will phosphorylate one nmole of poly(Gly:Tyr) 4:1 per minute at pH 7.5 at 30°C.
外形
Solution in 50 mM Tris pH 7.5, 0.05 mM EDTA, 1 mM DTT, 100 mM NaCl, 0.05% NP-40, and 50% glycerol.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin aIIb?3 to Initiate Outside-in Signaling in Platelets.
Wu Y
The Journal of Biological Chemistry (2015)
Ying Zhou et al.
Journal of the American Chemical Society, 136(40), 14031-14038 (2014-09-05)
Transcriptional activation of σ(54)-RNA polymerase holoenzyme (σ(54)-RNAP) in bacteria is dependent on a cis-acting DNA element (bacterial enhancer), which recruits the bacterial enhancer-binding protein to contact the holoenzyme via DNA looping. Using a constructive synthetic biology approach, we recapitulated such
R J Budde et al.
Preparative biochemistry, 23(4), 493-515 (1993-11-01)
A simple and effective method has been developed to purify the recombinant protein tyrosine kinase pp60c-src from a baculovirus-insect cell expression system. The procedure includes affinity chromatography and HPLC. Milligram quantities of protein have been isolated with an activity of
Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma. An array comparative genomic hybridization analysis.
Armengol G
Cancer Genetics and Cytogenetics (2007)
SH3 domain of c-Src governs its dynamics at focal adhesions and the cell membrane.
Machiyama H
FEBS Journal (2015)
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