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安全信息

S5069

Sigma-Aldrich

Anti-Superoxide Dismutase (MnSOD) (DD-17) antibody produced in rabbit

enhanced validation

affinity isolated antibody, buffered aqueous solution

别名:

Anti-IPO-B, Anti-Indophenoloxidase B, Anti-MNSOD, Anti-Manganese Dependent SOD, Anti-Manganese Superoxide Dismutase 2, Anti-Mitochodrial SOD, Anti-Mn-SOD, Anti-SOD2, Anti-Superoxide Dismutase 2

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About This Item

MDL编号:
MFCD06798545
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~24 kDa

种属反应性

rat, human

增强验证

independent
Learn more about Antibody Enhanced Validation

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using biotin/ExtraAvidin®-peroxidase staining of human heart sections
indirect immunofluorescence: 10-20 μg/mL using methanol-acetone-fixed rat NRK cells
western blot: 1-2 μg/mL using human HeLa mitochondria extract and a chemiluminescent detection reagent
western blot: 2-4 μg/mL using whole extract of rat brain and a chemiluminescent detection reagent

UniProt登记号

P04179

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SOD2(6648)
rat ... Sod2(24787)

相关类别

一般描述

Superoxide Dismutase (SOD) is a metalloprotein enzyme. It is widely distributed in the animal and plant kingdoms. The three common mammalian endogenous isozymes are the homodimeric copper-zinc SOD (Cu,ZnSOD, SOD1) found primarily in the cytosol, the homotetrameric glycosylated copper-zinc SOD, extracellular SOD (EC-SOD, SOD3), and the homotetrameric mitochondrial manganese SOD (MnSOD, SOD2). All three are nuclear-encoded. MnSOD is composed of four subunits, each containing one Mn2+.

免疫原

synthetic peptide corresponding to amino acid residues 183-199 of human superoxide dismutase (MnSOD) with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is conserved in many eukaryotes.

应用

The antibody may be detected by various immunochemical techniques including immunoblotting, co-immunoprecipitation assay (co-IP), immunoprecipitation, indirect immunofluorescence and immunohistochemistry.

生化/生理作用

Superoxide Dismutase (SOD) catalyzes the dismutation of the cytotoxic superoxide radical (O2 -) to molecular oxygen and hydrogen peroxide. Manganese SOD (MnSOD) has been proposed to function as a tumor suppressor by modulating the activity of redox-sensitive transcription factors and specific signal mediators. MnSOD is involved in detoxification.

外形

Solution in phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

法律信息

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000195440
0000195440
0000108210
055M4782V
093M4780

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Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt
Lai Y, et al.
International Journal of Molecular Medicine, 37(2), 369-377 (2016)
Myocardial ischemic tolerance in rats subjected to endurance exercise training during adaptation to chronic hypoxia
Alanova P, et al.
Journal of Applied Physiology, 122(6), 1452-1461 (2017)
SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma
Chang B, et al.
Scientific Reports, 6 (2016)
Wen-Su Wei et al.
Redox biology, 48, 102201-102201 (2021-12-06)
Reactive oxygen species (ROS) which are continuously generated mainly by mitochondria, have been proved to play an important role in the stress signaling of cancer cells. Moreover, pentatricopeptide repeat (PPR) proteins have been suggested to take part in mitochondrial metabolism.
Yuanhui Lai et al.
International journal of molecular medicine, 37(2), 369-377 (2015-12-29)
The sensitization of breast cancer stem cells (BrCSCs) to the inhibitive effects of radiotherapy through adjuvant therapy which targets oncogenic pathways represents a prospective strategy for improving the effect of radiation in patients with triple-negative breast cancer (TNBC). Mammalian target
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