S4945
Anti-SynCAM antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-IGSF4, Anti-Necl-2, Anti-RAI75, Anti-SgIGSF, Anti-Tslc1
产品名称
Anti-SynCAM antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 48 kDa
species reactivity
mouse, rat
technique(s)
immunohistochemistry: suitable using suitable for IHC on rat brain perfused with 4% paraformaldehyde
microarray: suitable
western blot: 0.5-1.0 μg/mL using mouse brain and rat brain extract (S1 fraction)
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Cadm1(54725)
rat ... Cadm1(363058)
Application
- Anti-SynCAM antibody produced in rabbit has been used in:
- immunoprecipitation
- immunoblotting
- immunohistochemistry
- immunostaining
- immunofluorescence
Biochem/physiol Actions
SynCAM is a neurological cell-adhesion protein that regulates the formation of synapses. Expression of synaptic cell adhesion molecule (SynCAM) in non-neuronal cells induces synaptic formation and affects synaptic function in hippocampal neurons. It functions as a homophilic cell adhesion molecule at the synapse. SynCAM is believed to interact with PDZ-domain synaptic proteins CASK and syntenin via its cytoplasmic tail.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-SynCAM is developed in rabbit using a synthetic peptide corresponding to amino acids located at the C-terminus of mouse SynCAM1 conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Synaptic cell adhesion molecule (SynCAM) is a brain-specific protein which has an immunoglobulin domain. It binds to intracellular PDZ-domain protein. SynCAMs have also been called nectin-like molecules (Necls). SynCAM1 is also known as Necl-2/ IGSF4/ RA175/ SgIGSF/ TSLC1. SynCAM contains an N-terminal signal peptide, three extracellular Ig domains, a single transmembrane region and a short C-terminal cytoplasmic domain. It is expressed only in brain and is localized to synapses.
SynCAM proteins consist of a C-terminal cytoplasmic domain, an N-terminal signaling domain and three extracellular immunoglobulin domains.. Anti-SynCAM antibody is specific for SynCAM in mouse and rats. The SynCAM1 immunizing peptide (mouse, amino acids 431-445) specifically inhibits the staining of the SynCAM band in immunoblotting.
Immunogen
This immunogen sequence is identical in human SynCAM1, highly conserved (90%) in the splice variant SynCAM2 and displays limited homology (55%) to SynCAM3.
synthetic peptide corresponding to amino acids 431-445 located at the C-terminus of mouse SynCAM1 conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Cadm1 expression and function in the mouse lens
De MA, et al.
Investigative Ophthalmology & Visual Science, 52(5), 2293-2299 (2011)
Johan Botling et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(1), 194-204 (2012-10-04)
Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multigene signatures in clinical practice is unclear
Ying Gao et al.
PloS one, 8(5), e64316-e64316 (2013-06-07)
Nectin-like molecule-2 (Necl-2), a junction molecule, is exclusively expressed by spermatogenic cells. It mediates homophilic interaction between germ cells and heterophilic interaction between Sertoli and germ cells. Knockout studies have shown that loss of Necl-2 causes male infertility, suggesting Necl-2-based
SynCAM, a synaptic adhesion molecule that drives synapse assembly
Biederer T, et al.
Science, 297(5586), 1525-1531 (2002)
Markus Missler
Trends in neurosciences, 26(4), 176-178 (2003-04-12)
A growing number of candidate genes has been implicated in linking the two sides of a synapse but definitive proof of a specific role for many of them is still scarce. Exploiting the vast amount of sequence data, a novel
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