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Merck
CN

S4939

N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-trifluoromethylcoumarin

proteasome substrate, ≥98% (HPLC), solid

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关于此项目

经验公式（希尔记法）:
C40H50N5O10F3
分子量:
817.85
UNSPSC Code:
12352204
PubChem Substance ID:
329824447
NACRES:
NA.32
MDL number:
MFCD03453017

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产品名称

N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-trifluoromethylcoumarin, ≥98% (HPLC), solid

SMILES string

CC(C)C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)Nc2ccc3c(OC(=O)C=C3C(F)(F)F)c2

InChI key

ZSJPCNKJLSJEQF-DWNBPJMTSA-N

InChI

1S/C40H50F3N5O10/c1-20(2)15-28(45-32(50)13-14-33(51)52)37(55)46-29(16-21(3)4)38(56)48-35(22(5)6)39(57)47-30(17-23-7-10-25(49)11-8-23)36(54)44-24-9-12-26-27(40(41,42)43)19-34(53)58-31(26)18-24/h7-12,18-22,28-30,35,49H,13-17H2,1-6H3,(H,44,54)(H,45,50)(H,46,55)(H,47,57)(H,48,56)(H,51,52)/t28-,29-,30-,35-/m0/s1

assay

≥98% (HPLC)

form

solid

solubility

DMF: 1 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

Quality Level

200

Biochem/physiol Actions

Chymotrypsin and multicatalytic endopeptidase complex: proteasome substrate similar to AMC derivative

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBZ1042
SLBX0310
SLBV9623
SLBK9191V
SLBH9589V

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Mafalda Santos et al.
Frontiers in molecular biosciences, 9, 809985-809985 (2022-05-20)
Serine tRNAs (tRNASer) are frequently overexpressed in tumors and associated with poor prognosis and increased risk of recurrence in breast cancer. Impairment of tRNA biogenesis and abundance also impacts proteome homeostasis, and activates protein quality control systems. Herein, we aimed
Ana Sofia Varanda et al.
RNA biology, 17(1), 135-149 (2019-10-02)
Deregulation of tRNAs, aminoacyl-tRNA synthetases (aaRS) or tRNA modifying enzymes, increase the level of protein synthesis errors (PSE) and are associated with several diseases, but the cause-effect mechanisms of these pathologies remain elusive. To clarify the role of PSE in

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