包含
sodium phosphate buffer as balance
质量水平
组成
Protein, ~25% Lowry
存货情况
not available in USA
杂质
Staphylococcal enterotoxin A (SEA), essentially free
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
2-8°C
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一般描述
Staphylococcal Enterotoxin B (SEB) is a potent exotoxin produced by Staphylococcus aureus, classified as a superantigen due to its unique ability to activate T-cells non-specifically. This activation occurs through the cross-linking of T-cell receptors (TCRs) and major histocompatibility complex (MHC) class II molecules, leading to a massive release of cytokines and an exaggerated immune response. SEB is associated with food poisoning and toxic shock syndrome, making it a critical agent for studying the mechanisms of bacterial pathogenesis and immune dysregulation.
In addition to its role in infectious disease research, SEB serves as a valuable tool for investigating autoimmune conditions and the development of immunotherapies. Its ability to induce T-cell activation and proliferation makes it an important reagent for exploring T-cell biology, including differentiation, memory formation, and the effects of various immunomodulators.
In addition to its role in infectious disease research, SEB serves as a valuable tool for investigating autoimmune conditions and the development of immunotherapies. Its ability to induce T-cell activation and proliferation makes it an important reagent for exploring T-cell biology, including differentiation, memory formation, and the effects of various immunomodulators.
应用
与 MHC II 类分子和 T 细胞受体(TCR)的特异性 Vβ 区结合的葡萄球菌肠毒素 B(SEB),可导致单核细胞/巨噬细胞和 T 淋巴细胞的激活,可用作超抗原和免疫系统激活剂。 SEB 可用作 SEB 检测系统开发中的参考材料。
生化/生理作用
T 淋巴细胞的超抗原。 与主要组织相容性复合体(MHC)抗原和 CD28 结合的免疫系统激活剂。
包装
包装尺寸基于蛋白质含量。
警示用语:
Danger
危险分类
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
高风险级别生物产品--毒素类产品
此项目有
Clarifying the mechanism of superantigen toxicity.
John D Fraser
PLoS biology, 9(9), e1001145-e1001145 (2011-09-21)
Oliver G Weingart et al.
Sensors (Basel, Switzerland), 12(2), 2324-2339 (2012-03-23)
Prevalent incidents support the notion that toxins, produced by bacteria, fungi, plants or animals are increasingly responsible for food poisoning or intoxication. Owing to their high toxicity some toxins are also regarded as potential biological warfare agents. Accordingly, control, detection
Winnie Bergstedt et al.
PloS one, 5(6), e11277-e11277 (2010-07-02)
Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential
Bacterial superantigens
Proft, T. and Fraser, J.D.
Clinical and Experimental Immunology, 133, 299-299 (2008)
A Herman et al.
Annual review of immunology, 9, 745-772 (1991-01-01)
Superantigens combine with MHC class-II molecules to form the ligands that stimulate T cells via the V beta element of the T-cell receptor. Two groups of superantigens have been described so far: first, endogenous murine products that include the Mls
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