产品名称
Anti-Syntaxin 7 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 35 kDa
species reactivity
rat
technique(s)
indirect immunofluorescence: 1:500-1:1000 using of rat kidney NRK cell line
western blot: 1:1000-1:2000 using whole cell extract of rat kidney NRK cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Stx7(60466)
Application
Anti-Syntaxin 7 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Syntaxin 7, localized on membrane compartments of late endosomes, facilitates fusion of late endosomes with lysosomes. The protein also helps in lysosomal biogenesis. Mutant syntaxin 7 lacking the transmembrane domain blocks endocytic transport from the early to late endosome. Syntaxin 7 has been described to play an important role during phagocytosis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Syntaxin 7 is a 35kDa protein and is a member of t-Soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) protein family. It is widely expressed in multiple tissues.
Immunogen
synthetic peptide corresponding to amino acids 131-149 located at the mid-region of rat syntaxin 7, conjugated to KLH. This sequence is highly conserved (two amino acid substitutions) in mouse and human syntaxin 7 (~80% identity).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Syntaxin 7 mediates endocytic trafficking to late endosomes
Nakamura N, et al.
The Journal of Biological Chemistry, 275(9), 6523-6529 (2000)
Syntaxins 13 and 7 function at distinct steps during phagocytosis
Collins RF, et al.
Journal of Immunology, 169(6), 3250-3256 (2002)
Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking
Prekeris R, et al.
Molecular Biology of the Cell, 10(11), 3891-3908 (1999)
B M Mullock et al.
Molecular biology of the cell, 11(9), 3137-3153 (2000-09-12)
Protein traffic from the cell surface or the trans-Golgi network reaches the lysosome via a series of endosomal compartments. One of the last steps in the endocytic pathway is the fusion of late endosomes with lysosomes. This process has been
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