生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 35 kDa
种属反应性
rat
技术
indirect immunofluorescence: 1:500-1:1000 using of rat kidney NRK cell line
western blot: 1:1000-1:2000 using whole cell extract of rat kidney NRK cell line
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
rat ... Stx7(60466)
一般描述
Syntaxin 7 is a 35kDa protein and is a member of t-Soluble N-ethylmaleimide-sensitive factor activating protein receptor (SNARE) protein family. It is widely expressed in multiple tissues.
免疫原
synthetic peptide corresponding to amino acids 131-149 located at the mid-region of rat syntaxin 7, conjugated to KLH. This sequence is highly conserved (two amino acid substitutions) in mouse and human syntaxin 7 (~80% identity).
应用
Anti-Syntaxin 7 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化/生理作用
Syntaxin 7, localized on membrane compartments of late endosomes, facilitates fusion of late endosomes with lysosomes. The protein also helps in lysosomal biogenesis. Mutant syntaxin 7 lacking the transmembrane domain blocks endocytic transport from the early to late endosome. Syntaxin 7 has been described to play an important role during phagocytosis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Syntaxin 7 mediates endocytic trafficking to late endosomes
Nakamura N, et al.
The Journal of Biological Chemistry, 275(9), 6523-6529 (2000)
Syntaxins 13 and 7 function at distinct steps during phagocytosis
Collins RF, et al.
Journal of Immunology, 169(6), 3250-3256 (2002)
Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking
Prekeris R, et al.
Molecular Biology of the Cell, 10(11), 3891-3908 (1999)
B M Mullock et al.
Molecular biology of the cell, 11(9), 3137-3153 (2000-09-12)
Protein traffic from the cell surface or the trans-Golgi network reaches the lysosome via a series of endosomal compartments. One of the last steps in the endocytic pathway is the fusion of late endosomes with lysosomes. This process has been
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