S4776
Somatotropin from human pituitary
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder
别名:
Growth Hormone, STH
biological source
human
recombinant
expressed in E. coli
sterility
non-sterile
assay
≥95% (SDS-PAGE)
form
lyophilized powder
potency
0.025-0.1 ng/mL cell proliferation using Nb2-11 cells per bioactivity ED50
mol wt
predicted mol wt ~22 kDa
drug control
Home Office Schedule 4.2
impurities
endotoxin, tested
solubility
PBS: 0.100 mL, clear, colorless (with 0.1% BSA )
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.
Application
Somatotropin or growth hormone has been used to study the molecular interactions of ephrin type-A receptor 4 precursor (EphA4) with the growth hormone receptor. It has also been used to induce differentiation in mammary epithelial cell line HC11.
Biochem/physiol Actions
Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores.
Physical form
Lyophilized from a 0.2 μm filtered solution in TBS (20 mM Tris, 0.15 M NaCl, pH 8.5) containing 50 μg of BSA per 1 μg of cytokine.
Preparation Note
It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Quantitative analysis of the expression of whey acidic protein (WAP) mRNA in the prolactin-responsive mouse mammary gland epithelial cell line, HC11
Kawamata, Yuji, et al
Journal of Reproduction and Development (2001)
Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
Takahiro Sawada
PLoS ONE (2017)
Kin-Sing Wong et al.
Journal of chromatography. A, 1478, 35-42 (2016-12-05)
Growth hormone (GH), or somatotropin, is a protein that may enhance physical performance and facilitate growth and wound healing. For this reason, growth hormones and their recombinant analogues are prohibited in human sports by the World Anti-Doping Agency (WADA) and
Maximilian Bielohuby et al.
Disease models & mechanisms, 7(11), 1263-1273 (2014-09-23)
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in clinical practice. However, intact
Lina Pednekar et al.
Frontiers in immunology, 7, 600-600 (2017-01-10)
Dendritic cells (DCs) are the most potent antigen-presenting cells capable of priming naïve T-cells. Its C-type lectin receptor, DC-SIGN, regulates a wide range of immune functions. Along with its role in HIV-1 pathogenesis through complement opsonization of the virus, DC-SIGN
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