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Merck
CN

S4760

N-琥珀酰-丙氨酸-丙氨酸-丙氨酸-p-硝基苯胺

elastase substrate, chromogenic, ≥98% (HPLC), powder

别名:

N-琥珀酰-L-丙氨酰-L-丙氨酰-L-丙氨酸4-硝基苯胺, N-琥珀酰-三-L-丙氨酸4-硝基苯胺

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关于此项目

经验公式（希尔记法）:
C19H25N5O8
化学文摘社编号:
52299-14-6
分子量:
451.43
NACRES:
NA.32
PubChem Substance ID:
24899617
UNSPSC Code:
12352204
EC Number:
257-823-5
MDL number:
MFCD00036774
Beilstein/REAXYS Number:
2928351

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产品名称

N-琥珀酰-丙氨酸-丙氨酸-丙氨酸-p-硝基苯胺, elastase substrate

InChI key

GVUGADOWXGKRAE-SRVKXCTJSA-N

InChI

1S/C19H25N5O8/c1-10(20-15(25)8-9-16(26)27)17(28)21-11(2)18(29)22-12(3)19(30)23-13-4-6-14(7-5-13)24(31)32/h4-7,10-12H,8-9H2,1-3H3,(H,20,25)(H,21,28)(H,22,29)(H,23,30)(H,26,27)/t10-,11-,12-/m0/s1

SMILES string

C[C@H](NC(=O)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)Nc1ccc(cc1)[N+]([O-])=O

assay

≥98% (HPLC)

form

powder

solubility

DMF: 25 mg/mL, clear, colorless to light yellow

storage temp.

2-8°C

Quality Level

200

General description

N-琥珀酰-Ala-Ala-Ala-对硝基苯胺是糜蛋白酶样丝氨酸蛋白酶、胰弹性蛋白酶和丝氨酸内肽酶的显色底物。
弹性蛋白酶底物。

Application

N-琥珀酰-Ala-Ala-Ala-对硝基苯胺作为底物用于
  • 筛选冻干蚯蚓纤溶酶中弹性蛋白酶的活性
  • 量化羊奶中的弹性蛋白酶的活性
  • 在丝氨酸蛋白酶抑制分析中筛选蜜蜂抑制剂

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000521131
0000521133
0000521132
0000521132
0000521133

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M Ogawa et al.
Research communications in chemical pathology and pharmacology, 55(2), 271-274 (1987-02-01)
A human urinary trypsin inhibitor preparation, MR-20, strongly inhibited granulocyte elastase activity. The concentration of MR-20 causing 50% inhibition of the hydrolysis of Suc(Ala) 3pNA by granulocyte elastase was estimated to be 6.4 X 10(-8) M (11 U/ml).
William R Swindell et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Tetrahexyldecyl Ascorbate (THDC) is an L-ascorbic acid precursor with improved stability and ability to penetrate the epidermis. The stability and transdermal penetration of THDC, however, may be compromised by the oxidant-rich environment of human skin. In this study, we show
Hu Wan et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 165(1), 36-41 (2013-03-19)
Spider-derived Kunitz-type serine protease inhibitors have been shown to exhibit plasmin and elastase inhibition activity and potassium channel blocking activity, but thus far, no additional roles for spider-derived chymotrypsin inhibitors have been elucidated. In this study, a spider (Araneus ventricosus)
Vinu S Siva et al.
Fish & shellfish immunology, 59, 1-8 (2016-11-05)
Serine protease inhibitors (SPIs) play a crucial role in regulation of both host and bacterial serine protease. They are classified into several protein families, where Kazal-type inhibitors are one of families with multi-domain. In the present study, the polymorphism of
Ulvi Kahraman Gürsoy et al.
Pathogens (Basel, Switzerland), 9(9) (2020-09-19)
Aim was to profile salivary total protease, Porphyromonas gingivalis gingipain, and neutrophil elastase activities in relation to the resolution of periodontal inflammation, salivary macrophage-derived chemokine (MDC), and macrophage inflammatory protein-1α concentrations. Nonsurgical periodontal treatment was performed in 24 periodontitis patients
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商品

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

实验方案

Enzymatic Assay of Elastase (EC 3.4.21.36)

Enzymatic Assay of Elastase (EC 3.4.21.36), a continuous spectrophotometric rate determination.

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