S4572
SANT-1 型
≥98% (HPLC), powder, SHH antagonist
别名:
（4-苄基-哌嗪-1-基）-（3,5-二甲基-1-苯基-1H-吡唑-4-基亚甲基）-胺
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关于此项目
经验公式（希尔记法）:
C23H27N5
化学文摘社编号:
分子量:
373.49
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
SANT-1 型, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4
InChI
1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
InChI key
FOORCIAZMIWALX-JJIBRWJFSA-N
Application
- SANT-1已被用于：治疗细胞并研究并研究SANT1介导的抑制对刺猬信号传导的影响
- 功能性人胰腺细胞的体外生成
- 处理间变性淋巴瘤激酶（ALK）阳性间变性大细胞淋巴瘤细胞2和慢性淋巴细胞白血病细胞3引起SANT-1诱导的细胞死亡
Biochem/physiol Actions
众所周知SANT-1通过Ras/NF-κB途径诱导胶质母细胞瘤细胞凋亡。
SANT-1 是一种有效的 sonic hedgehog 信号途径（Shh）拮抗剂，通过与平滑（Smo）受体结合直接抑制。SANT-1 抑制野生型和致癌 Smo 的效率相同。
SANT-1 是一种有效的 sonic hedgehog 信号途径（Shh）拮抗剂。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
培养和表征CSC群体的癌症干细胞培养基、球状体培养板和癌症干细胞标志物。
Deobrat Dixit et al.
Cancer letters, 336(2), 347-358 (2013-04-04)
Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade
Felicia W Pagliuca et al.
Cell, 159(2), 428-439 (2014-10-11)
The generation of insulin-producing pancreatic β cells from stem cells in vitro would provide an unprecedented cell source for drug discovery and cell transplantation therapy in diabetes. However, insulin-producing cells previously generated from human pluripotent stem cells (hPSC) lack many
P Desch et al.
Oncogene, 29(35), 4885-4895 (2010-07-07)
The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in healthy B lymphocytes. Profiling of cognate Hh pathway members
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S4572-25MG | 04061833221310 |
| S4572-5MG | 04061836927806 |