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Merck
CN

S4568

SCH 58261

≥98% (HPLC), adenosine receptor antagonist, solid

别名:

7-(2-苯乙基)-5-氨基-2-(2-呋喃基)-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]嘧啶

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关于此项目

经验公式(希尔记法):
C18H15N7O
化学文摘社编号:
分子量:
345.36
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
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产品名称

SCH 58261, ≥98% (HPLC), solid

Quality Level

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble

SMILES string

Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5

InChI

1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)

InChI key

UTLPKQYUXOEJIL-UHFFFAOYSA-N

Application

SCH 58261被用于阻断A2α腺苷酸受体,以研究神经元中前列腺酸性磷酸酶的信号传导。4

Biochem/physiol Actions

A2A 腺苷受体拮抗剂。
SCH 58261能够降低TNF-α、Fas-L、Bax表达以及JNK-MAPK通路的活化水平。它具有神经保护作用,因为它可以减少神经元的脱髓鞘。 SCH 58261能够提高多巴胺的分泌浓度并引发运动致敏,这是一个有吸引力的潜在帕金森氏病治疗方法。

Features and Benefits

《受体分类和信号转导》手册的 腺苷受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cristiani F Bortolatto et al.
Metabolic brain disease, 32(6), 1919-1927 (2017-08-11)
The aim of the present study was to investigate the effects of SCH58261, a selective adenosine A
Mushtaq A Ansari et al.
Molecular and cellular neurosciences, 82, 76-87 (2017-05-04)
Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by stereotypical repetitive behavior, impaired social interaction, and deficits in communication. The BTBR T
Sheikh F Ahmad et al.
Journal of neuroimmunology, 311, 59-67 (2017-08-16)
Autism is a complex heterogeneous neurodevelopmental disorder; previous studies have identified altered immune responses among individuals diagnosed with autism. An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in neurodevelopmental behavioral and autism



全球贸易项目编号

货号GTIN
S4568-25MG04061832093512
S4568-5MG04061836927660