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![MCA-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676-DNP-Lys-Arg-Arg-NH2 ≥90% (HPLC)](/deepweb/assets/sigmaaldrich/product/images/375/511/f63f11a7-86de-45c4-95a0-7afa616bb265/640/f63f11a7-86de-45c4-95a0-7afa616bb265.jpg)
![[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676 trifluoroacetate salt ≥95% (HPLC), solid](/deepweb/assets/sigmaaldrich/product/images/296/089/259ad19e-25e1-4604-9077-8d4dbea518b6/640/259ad19e-25e1-4604-9077-8d4dbea518b6.jpg)
重组
expressed in HEK 293 cells (C-terminal FLAG tagged)
质量水平
方案
≥90% (SDS-PAGE)
表单
buffered aqueous solution
比活
≥10,000 units/mg protein
UniProt登记号
运输
wet ice
储存温度
2-8°C
基因信息
human ... BACE1(23621)
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应用
人 β-分泌酶或BACE1已被用于研究淀粉样蛋白前体蛋白与β-分泌酶之间的结合反应。 它也已被用于BACE1分析。
生化/生理作用
BACE1（β-分泌酶或β-位点APP裂解酶）是一种跨膜蛋白酶，负责淀粉样前体蛋白（APP）的β位点裂解，从而产生淀粉样 β 淀粉样蛋白肽（Aβ）。大脑中Aβ的积累是阿尔茨海默氏症进展的主要原因，因此BACE1是发现抑制剂药物的靶标。
BACE1（β位APP裂解酶1）是一种跨膜天冬氨酰蛋白酶，负责裂解淀粉样前体蛋白 (APP)。BACE1介导的淀粉样前体蛋白 (APP)的裂解是致病性淀粉样β肽生成过程中的第一步，因此使其成为阿尔茨海默氏病 (AD)的主要药物靶标。在患有轻度认知障碍（MCI）和AD的患者的脑脊液中发现BACE1的酶活性水平升高，从而表明BACE1酶活性在MCI向AD转化中的重要性。
单位定义
在37℃温度，pH4.5下，一个单位1分钟将水解1.0甲酚7-甲氧基香豆素-4-乙酰基-[Asn670, Leu671]--淀粉样β/ A4前体蛋白770片段667-676-（2,4-二硝基苯基）-Lys-Arg -Arg酰胺底物。
外形
溶于 20 mM Hepes，125 mM NaCl (pH 7.4中。
储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Giovanni Zuliani et al.
Journal of neurochemistry, 159(3), 629-637 (2021-09-18)
Beta-secretase 1 (BACE1) is considered as the key enzyme in amyloid-β formation. Previous works suggest that high BACE1 activity may be present in brain, cerebrospinal fluid and serum of patients with late-onset Alzheimer's disease (LOAD) as well as mild cognitive
Hirotsugu Ogi et al.
Biosensors & bioelectronics, 40(1), 200-205 (2012-08-04)
High-frequency (~ 55 MHz) wireless quartz-crystal microbalance biosensor was used for studying heterogeneous deposition behavior of Aβ(1-40) peptide on Aβ(1-42) nuclei, which were grown under the stirring agitation and 200-kHz ultrasonication at pH 2.2, 4.6, and 7.4. The deposition reaction
Dennis J Selkoe
Nature cell biology, 6(11), 1054-1061 (2004-11-02)
The salutary intersection of fundamental cell biology with the study of disease is well illustrated by the emerging elucidation of neurodegenerative disorders. Novel mechanisms in cell biology have been uncovered through disease-orientated research; for example, the discovery of presenilin as
cceleration of deposition of peptide on ultrasonically formed nucleus studied by wireless quartz-crystal-microbalance biosenso
Hirotsugu Ogi
Biosensors, 40(1) (2013)
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.
Vassar R
Journal of Neurochemistry (2014)
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