S4063
SCH-202676 hydrobromide
98%
别名:
N-(2,3-diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine hydrobromide
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关于此项目
经验公式（希尔记法）:
C15H16BrN3S
化学文摘社编号:
分子量:
350.28
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
YJYGOWVFDGULLL-GEEYTBSJSA-N
SMILES string
Br.C\N=C1\SN(c2ccccc2)C(=N1)c3ccccc3
InChI
1S/C15H13N3S.BrH/c1-16-15-17-14(12-8-4-2-5-9-12)18(19-15)13-10-6-3-7-11-13;/h2-11H,1H3;1H/b16-15+;
assay
98%
mp
240.0-240.8 °C (lit.)
solubility
DMSO: 40 mg/mL, H2O: insoluble
General description
Modulates radioligand binding to various GPCRs including the human μ-, δ-, and κ-opiod, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors.
Shown to modulate radioligand binding to various GPCRs including the human μ-, δ-, and κ-opiod, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors. Modulation is G-protein independent and is both selective and reversible.
Application
SCH-202676 hydrobromide may be used in G protein-coupled receptor-mediated cell signaling studies.
Biochem/physiol Actions
Allosteric agonist and antagonist of G-protein coupled receptors (GPCRs).
SCH-202676 inhibits the binding of both agonists and antagonists to G protein-coupled receptors. It also inhibits human μ-, δ-, and κ-opioid, α- and β-adrenergic, muscarinic M1 and M2, and dopaminergic D1 and D2 receptors. Some reports indicates thiol modification as the mechanism of inhibition rather than allosteric modulation.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Anna M Lewandowicz et al.
British journal of pharmacology, 147(4), 422-429 (2006-01-13)
1. Previous studies suggest that the thiadiazole compound SCH-202676 (N-(2,3-diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine) acts as an allosteric modulator of a variety of structurally distinct G protein-coupled receptors (GPCRs). It was postulated that SCH-202676 would directly bind a structural motif in the receptor molecule
A B Fawzi et al.
Molecular pharmacology, 59(1), 30-37 (2000-12-23)
A novel thiadiazole compound, SCH-202676 (N-(2,3-diphenyl-1,2, 4-thiadiazol-5-(2H)-ylidene)methanamine), has been identified as an inhibitor of both agonist and antagonist binding to G protein-coupled receptors (GPCRs). SCH-202676 inhibited radioligand binding to a number of structurally distinct, heterologously expressed GPCRs, including the human
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