S3944
SEW2871
≥98% (HPLC), solid
别名:
5- [4-苯基-5-(三氟甲基)-2-噻吩基]-3- [3-(三氟甲基)苯基]-1,2,4-恶二唑
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H10F6N2OS
化学文摘社编号:
分子量:
440.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
产品名称
SEW2871, ≥98% (HPLC), solid
InChI
1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
SMILES string
FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
InChI key
OYMNPJXKQVTQTR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
white
mp
94.5-95.3 °C
solubility
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
Gene Information
human ... S1PR1(1901), S1PR2(9294), S1PR3(1903), S1PR4(8698), S1PR5(53637)
Application
SEW2871可用于模拟HUVEC中的1-磷酸鞘氨醇的作用，以研究长穿透素3所产生的先天免疫力。
SEW2871已被用作鞘氨醇-1磷酸酯（S1P）受体激动剂，用于测定重构血浆载脂蛋白（ApoM) /S1P对小鼠血管通透性的作用。
Biochem/physiol Actions
SEW2871是1-磷酸鞘氨醇受体的选择性激动剂。其会通过显著延长室性心动过速和室颤的持续时间，加剧再灌注性心律失常。 SEW2871可通过影响淋巴细胞归巢和细胞迁移来调节炎症反应。 通过抑制促炎分子，SEW2871可减少因缺血引起的急性肾衰竭。
新型选择性人鞘氨醇-1-磷酸亚型1（S1P1）受体激动剂。
Packaging
光敏。
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Timothy M Doyle et al.
Pain, 161(9), 2107-2118 (2020-04-18)
Morphine-induced alterations in sphingolipid metabolism in the spinal cord and increased formation of the bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) have been implicated in the development of morphine-induced hyperalgesia (OIH; increased pain sensitivity) and antinociceptive tolerance. These adverse effects hamper opioid
Y-Hh Lien et al.
Kidney international, 69(9), 1601-1608 (2006-03-31)
The pathogenesis of renal ischemia/reperfusion (I/R) injury involves activating several signal transduction cascade systems in endothelial cells. Sphingosine 1-phospate (S1P) maintains endothelial cell integrity and inhibits lymphocyte egress via the specific S1P(1) receptor, and may play a role in reducing
David T Bolick et al.
Arteriosclerosis, thrombosis, and vascular biology, 25(5), 976-981 (2005-03-12)
Endothelial activation and monocyte adhesion to endothelium are key events in inflammation. Sphingosine-1-phosphate (S1P) is a sphingolipid that binds to G protein-coupled receptors on endothelial cells (ECs). We examined the role of S1P in modulating endothelial activation and monocyte-EC interactions
Zhoumou Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(21), 10557-10562 (2019-05-10)
Neuropathic pain afflicts millions of individuals and represents a major health problem for which there is limited effective and safe therapy. Emerging literature links altered sphingolipid metabolism to nociceptive processing. However, the neuropharmacology of sphingolipid signaling in the central nervous
Yayoi T Tsukada et al.
Journal of cardiovascular pharmacology, 50(6), 660-669 (2007-12-20)
Sphingosine-1-phosphate (S1P) has been considered to play an important role in ischemia/reperfusion (I/R) injury. We used SEW2871 (SEW), a novel receptor-selective agonist for S1P1, to elucidate the role of S1P1 in myocardial I/R. Isolated perfused rat hearts exposed to S1P
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