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Merck
CN
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文件

安全信息

S3523

Sigma-Aldrich

表面肌动蛋白

from Bacillus subtilis, ≥98.0% (HPLC)

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别名:
surfactin C
经验公式（希尔记法）:
C53H93N7O13
CAS号:
24730-31-2
分子量:
1036.34
UNSPSC代码:
51101500
PubChem化学物质编号:
24899562
NACRES:
NA.85

生物来源

Bacillus subtilis

质量水平

200

描述

zwitterionic

检测方案

≥98.0% (HPLC)

形式

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

颜色

white to faint yellow

CMC

7.5-20 μmol/L (depending on methods)

溶解性

ethanol: soluble 10 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
fungi
mycoplasma
neoplastics
viruses

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES字符串

CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1

InChI

1S/C53H93N7O13/c1-30(2)20-18-16-14-13-15-17-19-21-36-28-43(61)54-37(22-23-44(62)63)47(66)55-38(24-31(3)4)48(67)57-40(26-33(7)8)51(70)60-46(35(11)12)52(71)58-41(29-45(64)65)50(69)56-39(25-32(5)6)49(68)59-42(27-34(9)10)53(72)73-36/h30-42,46H,13-29H2,1-12H3,(H,54,61)(H,55,66)(H,56,69)(H,57,67)(H,58,71)(H,59,68)(H,60,70)(H,62,63)(H,64,65)/t36-,37+,38+,39-,40-,41+,42+,46+/m1/s1

InChI key

NJGWOFRZMQRKHT-WGVNQGGSSA-N

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相关类别

一般描述

化学结构：肽

应用

表面活性素可用作表面活性剂用于介导单价和二价阳离子，如钙在脂质双层膜上的流通。 它还可用于研究抗肿瘤活性、抗包膜病毒活性、抗巨大芽孢杆菌原生质体活性以及抗支原体活性。

生化/生理作用

表面活性素是一种脂肽抗生素，由具有长脂肪酸部分的一个β-羟基脂肪酸和七个氨基酸组成。 其中三个具有D构象。 它是一种强大的生物表面活性剂，可引起红细胞和细菌的溶解。 它也是一种凝血抑制剂。 表面活性素被认为是通过与膜发生物理化学相互作用而对膜进行破坏或解体。

其他说明

保存于密闭容器内，置于干燥通风处。置于干燥处保存。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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M M Nakano et al.
Journal of bacteriology, 170(12), 5662-5668 (1988-12-01)
Surfactin is a lipopeptide antibiotic produced by the cells of Bacillus subtilis ATCC 21332. A genetic locus responsible for surfactin production (sfp) was transferred from ATCC 21332 to JH642, a derivative of the standard B. subtilis 168. To study the
Catherine R Stewart et al.
Journal of bacteriology, 193(21), 5971-5984 (2011-09-06)
When Legionella pneumophila grows on agar plates, it secretes a surfactant that promotes flagellum- and pilus-independent "sliding" motility. We isolated three mutants that were defective for surfactant. The first two had mutations in genes predicted to encode cytoplasmic enzymes involved
K Tsuge et al.
Antimicrobial agents and chemotherapy, 45(12), 3566-3573 (2001-11-16)
Surfactin is a cyclic lipopeptide biosurfactant. Transposon mutagenesis was performed in Bacillus subtilis strain 168, and a surfactin-susceptible mutant, strain 801, was isolated. Analysis of the region of insertion revealed that yerP was the determinant of surfactin self-resistance. YerP had
Guillaume Henry et al.
Cellular microbiology, 13(11), 1824-1837 (2011-08-16)
The lipopeptide surfactin secreted by plant-beneficial bacilli has crucial biological functions among which the ability to stimulate immune-related responses in host tissues. This phenomenon is important for biological control of plant diseases but its molecular basis is still poorly understood.
Darlane Wellen Freitas de Oliveira et al.
Colloids and surfaces. B, Biointerfaces, 101, 34-43 (2012-07-17)
In this work a low cost medium for the production of a biosurfactant by Bacillus subtilis LAMI005 and the kinetics of surfactin production considering the effect of initial substrate concentration were investigated. First, cashew apple juice supplementation for optimal production
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