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Merck
CN

S3523

表面肌动蛋白

from Bacillus subtilis, ≥98.0% (HPLC)

别名:

surfactin C

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关于此项目

经验公式(希尔记法):
C53H93N7O13
化学文摘社编号:
分子量:
1036.34
UNSPSC Code:
51102829
PubChem Substance ID:
NACRES:
NA.85
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InChI key

NJGWOFRZMQRKHT-WGVNQGGSSA-N

biological source

Bacillus subtilis

SMILES string

CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1

InChI

1S/C53H93N7O13/c1-30(2)20-18-16-14-13-15-17-19-21-36-28-43(61)54-37(22-23-44(62)63)47(66)55-38(24-31(3)4)48(67)57-40(26-33(7)8)51(70)60-46(35(11)12)52(71)58-41(29-45(64)65)50(69)56-39(25-32(5)6)49(68)59-42(27-34(9)10)53(72)73-36/h30-42,46H,13-29H2,1-12H3,(H,54,61)(H,55,66)(H,56,69)(H,57,67)(H,58,71)(H,59,68)(H,60,70)(H,62,63)(H,64,65)/t36-,37+,38+,39-,40-,41+,42+,46+/m1/s1

description

zwitterionic

assay

≥98.0% (HPLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

color

white to faint yellow

CMC

7.5-20 μmol/L (depending on methods)

solubility

ethanol: soluble 10 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, mycoplasma, neoplastics, viruses

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

General description

化学结构:肽

Application

表面活性素可用作表面活性剂用于介导单价和二价阳离子,如钙在脂质双层膜上的流通。 它还可用于研究抗肿瘤活性、抗包膜病毒活性、抗巨大芽孢杆菌原生质体活性以及抗支原体活性

Biochem/physiol Actions

表面活性素是一种脂肽抗生素,由具有长脂肪酸部分的一个β-羟基脂肪酸和七个氨基酸组成。 其中三个具有D构象。 它是一种强大的生物表面活性剂,可引起红细胞和细菌的溶解。 它也是一种凝血抑制剂。 表面活性素被认为是通过与膜发生物理化学相互作用而对膜进行破坏或解体

Other Notes

保存于密闭容器内,置于干燥通风处。置于干燥处保存。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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M M Nakano et al.
Journal of bacteriology, 170(12), 5662-5668 (1988-12-01)
Surfactin is a lipopeptide antibiotic produced by the cells of Bacillus subtilis ATCC 21332. A genetic locus responsible for surfactin production (sfp) was transferred from ATCC 21332 to JH642, a derivative of the standard B. subtilis 168. To study the
K Tsuge et al.
Antimicrobial agents and chemotherapy, 45(12), 3566-3573 (2001-11-16)
Surfactin is a cyclic lipopeptide biosurfactant. Transposon mutagenesis was performed in Bacillus subtilis strain 168, and a surfactin-susceptible mutant, strain 801, was isolated. Analysis of the region of insertion revealed that yerP was the determinant of surfactin self-resistance. YerP had
Junfeng Zhao et al.
Journal of industrial microbiology & biotechnology, 39(6), 889-896 (2012-02-22)
Genome shuffling is an efficient approach for the rapid improvement of the yield of secondary metabolites. This study was undertaken to enhance the yield of surfactin produced by Bacillus amyloliquefaciens ES-2-4 using genome shuffling and to examine changes in SrfA
N Behary et al.
Colloids and surfaces. B, Biointerfaces, 90, 137-143 (2011-11-08)
This article deals with an alternative method for bio-separation of surfactin produced by Bacillus subtilis using sorption method on nonwoven PET (polyethylene terephthalate) fibrous membranes functionalized with chitosan. In the first part of the study, surface functionalization of the PET
Darlane Wellen Freitas de Oliveira et al.
Colloids and surfaces. B, Biointerfaces, 101, 34-43 (2012-07-17)
In this work a low cost medium for the production of a biosurfactant by Bacillus subtilis LAMI005 and the kinetics of surfactin production considering the effect of initial substrate concentration were investigated. First, cashew apple juice supplementation for optimal production

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