S3132
硒-L-蛋氨酸
≥98% (TLC), powder, IgE expression inhibitor
别名:
（S）-2-氨基-4-（甲基硒基）丁酸
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关于此项目
线性分子式:
CH3SeCH2CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
196.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
硒-L-蛋氨酸, ≥98% (TLC), powder
SMILES string
C[Se]CC[C@H](N)C(O)=O
InChI
1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI key
RJFAYQIBOAGBLC-BYPYZUCNSA-N
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
storage temp.
−20°C
Quality Level
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相关类别
Biochem/physiol Actions
L-硒代蛋氨酸(SeMet)能够抑制特应性皮炎(AD)样皮损。它还能抑制总免疫球蛋白E (IgE)和白介素4 (IL-4)的表达。它可通过饮食被鱼类吸收，因此会造成生态毒性。
硒-L-蛋氨酸显示出抗氧化活性，并且已表明能增加内皮细胞中谷胱甘肽过氧化物酶的活性。 谷胱甘肽过氧化物酶保护细胞免受氧化损伤，例如DNA 链断裂、突变和基于蛋白酪氨酸的信号传导的干扰，以及由于过量亚硝酸盐引起的3-硝基酪氨酸形成的其他蛋白质功能。向癌细胞系（MCF-7/S 乳腺癌，DU-145 前列腺癌细胞和UACC-375 黑素瘤）给予硒-L-甲硫氨酸处理，导致细胞凋亡和异常有丝分裂。这些人肿瘤细胞系在微摩尔范围（45至130μM）内表现出硒代蛋氨酸的剂量依赖性生长抑制，而正常成纤维细胞的生长抑制需要 1mM 硒代蛋氨酸。
Application
L-硒代蛋氨酸可用于：
- 用于日本青鳉胚胎的毒性研究
- 研究其对怀孕长尾猕猴硒状态指标的影响（食蟹猴）
- 为单波长反常色散(SAD)相位标记蛋白质
硒-L-蛋氨酸已用于：
- 作为处理日本青鳉鱼胚胎的非化学应激源
- 标记蛋白质，用于单波长异常色散（SAD）定相
- 研究硒-L-蛋氨酸对 4T1 小鼠乳腺癌的分布和抑制作用
General description
L-硒代蛋氨酸(SeMet)是硒的有机形式，存在于耐金属贪铜菌中。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
250.3 - 346.3 °F
flash_point_c
121.3 - 174.6 °C
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商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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