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方案
>98% (HPLC)
表单
solid
颜色
white
溶解性
H2O: soluble 11 mg/mL
SMILES字符串
Br[H].Oc1ccc(cc1O)C2CNCc3sccc23
InChI
1S/C13H13NO2S.BrH/c15-11-2-1-8(5-12(11)16)10-6-14-7-13-9(10)3-4-17-13;/h1-5,10,14-16H,6-7H2;1H
InChI key
QAIGGSDECIJPNW-UHFFFAOYSA-N
基因信息
human ... DRD1(1812)
应用
SKF-89626 hydrobromide may be used in dopaminergic cell signaling studies.
生化/生理作用
D1 dopamine receptor agonist.
SKF-89626 is an isoquinoline derivative that fully antagonizes dopamine D1 receptor and stimulates adenylate cyclase and modulates dopaminergic-mediated cell responses.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
E B Nielsen et al.
European journal of pharmacology, 160(2), 253-262 (1989-01-31)
Dopamine (DA) D-1 and D-2 receptor agonists and antagonists were characterized in receptor binding and adenylate cyclase assays with respect to affinity, selectivity and efficacy. The ability of the ligands to interact with the discriminative stimulus effects of d-amphetamine (AMPH)
P H Andersen et al.
European journal of pharmacology, 188(6), 335-347 (1990-06-12)
Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds
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