所有图片(3)
About This Item
线性分子式:
HOC6H4COONa
CAS号:
分子量:
160.10
Beilstein:
3732792
EC 号:
MDL编号:
UNSPSC代码:
12352302
PubChem化学物质编号:
NACRES:
NA.25
方案:
≥99.5% (titration)
表单:
crystalline
溶解性:
water: 575.7 g/L at 25 °C (77 °F)
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质量水平
产品线
ReagentPlus®
方案
≥99.5% (titration)
表单
crystalline
颜色
white
有效pH范围
6.85 (26.3 °C)
mp
>300 °C (lit.)
溶解性
water: 575.7 g/L at 25 °C (77 °F)
SMILES字符串
[Na+].Oc1ccccc1C([O-])=O
InChI
1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
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一般描述
水杨酸钠是阿司匹林中的活性成分，阿司匹林是解热，消炎镇痛常用药物。大量服用水杨酸钠会引起暂时听力丧失和耳鸣。使用水杨酸钠长期治疗会长期降低耳蜗分泌，降低体内化合物活性电位幅度和体外神经退化。杏仁外侧核水杨酸钠处理后会改变音调和兴奋性，导致听觉皮层过度活动。水杨酸钠能够减弱细胞内-Finkel−Biskis−Jinkins鼠成骨肉瘤病毒（c-fos）表达和海马区域 δ-FosB蛋白质，影响空间记忆和学习。水杨酸钠影响大脑齿状回区域神经发生。
应用
水杨酸钠可用于：
- 诱导大鼠耳鸣，高敏样行为以及和杏仁体直接融合，检测区域场电位。
- 通过脉冲前抑制行为（PPI），来诱导和确定耳鸣。通过Morris水迷宫测试确定它对对于学习和记忆的抑制作用，以及之后的大鼠基因表达研下丘背皮质的听觉反应究。
- 用来增强γ氨基酸丁酸(GABA)能抑制，增强下丘背皮质（ICd）的听觉反应，可以通过微离子电泳技术检测。
法律信息
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
208.9 °F - Pensky-Martens closed cup
闪点(°C)
98.3 °C - Pensky-Martens closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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