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Merck
CN
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安全信息

S2647

Sigma-Aldrich

壮观霉素 二盐酸盐 五水合物

powder, γ-irradiated

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About This Item

经验公式（希尔记法）:
C14H24N2O7 · 2HCl · 5H2O
CAS号:
22189-32-8
分子量:
495.35
EC 号:
244-554-3
MDL编号:
MFCD00150886
UNSPSC代码:
12352200
PubChem化学物质编号:
24899532
NACRES:
NA.85

生物来源

synthetic (inorganic)

质量水平

200

等级

for molecular biology

无菌性

γ-irradiated

形式

powder

效能

≥500 μg per mg

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

颜色

white to off-white

溶解性

H2O: soluble at 

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

适用性

nonselective for Escherichia coli
nonselective for coliforms

SMILES字符串

O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O

InChI

1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1

InChI key

DCHJOVNPPSBWHK-UXXUFHFZSA-N

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一般描述

Chemical structure: aminoglycoside

应用

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

生化/生理作用

作用机制：壮观霉素通过与细菌30S核糖体亚基结合并干扰肽基tRNA易位而抑制蛋白质合成和延伸。

抗性机制：rpsE（核糖体蛋白S5的基因）突变可阻止壮观霉素的结合。氨基糖苷-3′-腺苷转移酶基因（aadA）也能使细菌产生抗性。

抗菌谱：壮观霉素能够对抗革兰氏阴性和革兰氏阳性菌。

包装

100MG

注意

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

制备说明

直接在小瓶中用无菌水配制储存液 (10mg/mL)。储存液在 2-8°C 下可保存数周，在 -20°C 下可长期保存。

其他说明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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K Matsumoto et al.
Journal of bacteriology, 180(1), 100-106 (1998-01-09)
The psd gene of Bacillus subtilis Marburg, encoding phosphatidylserine decarboxylase, has been cloned and sequenced. It encodes a polypeptide of 263 amino acid residues (deduced molecular weight of 29,689) and is located just downstream of pss, the structural gene for
Praveen Kumar et al.
Journal of separation science, 35(4), 498-504 (2012-01-28)
The effect of mobile-phase constituents (pH and ionic strength) and chromatographic behaviour of ten aminoglycosides (streptomycin, dihydrostreptomycin, spectinomycin, apramycin, paramomycin, kanamycin A, gentamycin C1, gentamycin C2/C2a, gentamycin C1a and neomycin) in the bare silica, amino, amide and zwitterionic phases of
Susanna Ricci et al.
Infection and immunity, 70(9), 4968-4976 (2002-08-17)
Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the peroxide regulator PerR, in an M1 serotype of Streptococcus pyogenes. To determine
Amber M Hotto et al.
G3 (Bethesda, Md.), 1(7), 559-570 (2012-03-03)
Noncoding RNAs (ncRNA) are widely expressed in both prokaryotes and eukaryotes. Eukaryotic ncRNAs are commonly micro- and small-interfering RNAs (18-25 nt) involved in posttranscriptional gene silencing, whereas prokaryotic ncRNAs vary in size and are involved in various aspects of gene
Tarinee Tungsuchat-Huang et al.
Plant molecular biology, 76(3-5), 453-461 (2011-01-05)
Identification of a genetically stable Nicotiana tabacum (tobacco) plant with a uniform population of transformed plastid genomes (ptDNA) takes two cycles of plant regeneration from chimeric leaves and analysis of multiple shoots by Southern probing in each cycle. Visual detection
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