所有图片(1)
别名:
R-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
经验公式（希尔记法）:
C16H16ClNO2 · HBr
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质量水平
检测方案
≥98% (HPLC)
形式
solid
旋光性
[α]22/D +15.14°, c = 0.52 in DMF(lit.)
储存条件
desiccated
protect from light
颜色
white to off-white
溶解性
H2O: 6 mg/mL
DMSO: soluble
SMILES字符串
Br[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3
InChI
1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1
InChI key
RMIJGBMRNYUZRG-BTQNPOSSSA-N
应用
R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:
- to test it effect on the spike firing in rat retinal ganglion cells
- in human embryonic kidney (HEK) 293T cells
- to test its inhibitory effect in microglial cells
生化/生理作用
SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
R J Vermeulen et al.
European journal of pharmacology, 235(1), 143-147 (1993-04-22)
The alleged selective, high efficacy dopamine D1 receptor agonist, SKF 81297 (0.05-0.3 mg/kg i.m.), induced rotational behaviour away from the lesion and stimulated use of the dominant right hand in unilaterally (left side) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rhesus monkeys (Macaca mulatta). The
C. Reavill et al.
Behavioural pharmacology, 4(2), 135-146 (1993-04-01)
A range of selective dopamine D1 and D2 receptor agonists and antagonists was used to characterize to the discriminative stimuli produced by d-amphetamine (0.5mg/kg) and the D1 agonists SKF 81297 (0.1mg/kg). In rats trained to discriminate d-amphetamine (0.5mg/kg) from saline
Asim J Rashid et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(2), 654-659 (2006-12-30)
We demonstrate a heteromeric D1-D2 dopamine receptor signaling complex in brain that is coupled to Gq/11 and requires agonist binding to both receptors for G protein activation and intracellular calcium release. The D1 agonist SKF83959 was identified as a specific
Maximilian Stalter et al.
Cell reports, 30(1), 164-172 (2020-01-09)
The neurotransmitter dopamine, which acts via the D1-like receptor (D1R) and D2-like receptor (D2R) family, may play an important role in gating sensory information to the prefrontal cortex (PFC). We tested this hypothesis in awake macaques and recorded visual motion-direction
Rochellys Diaz Heijtz et al.
Behavioral and brain functions : BBF, 2, 18-18 (2006-05-30)
Molecular genetic studies suggest the dopamine D1 receptor (D1R) may be implicated in attention-deficit/hyperactivity disorder (ADHD). As little is known about the potential motor role of D1R in ADHD, animal models may provide important insights into this issue. We investigated
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