推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
whole antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
包含
15 mM sodium azide
种属反应性
human
技术
western blot: 1:400
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SPTA1(6708) , SPTB(6710) , SPTBN1(6711) , SPTBN2(6712) , SPTBN4(57731) , SPTBN5(51332)
一般描述
Spectrin is a multifunctional protein that has lipid-binding sites within CH (calponin-homology) tandem domains, a PH (pleckstrin homology) domain and triple helical segments. It is located on chromosome 1q23.1.
Spectrin is the major cytoskeletal component in erythrocytes. It is composed of two types of polypeptides known as α and β with molecular weights of 240 and 220 kDa, respectively. The α- and β-chains form heterotetramers which are linked end-to-end via oligomeric actin and band 4.1 protein.
特异性
The antibody reacts specifically with the α and β chains of human erythrocyte spectrin.
免疫原
spectrin from freshly prepared human erythrocyte ghosts.
应用
Anti-Spectrin antibody has been used in western blotting immunofluorescence and immunostaining.
生化/生理作用
Spectrins modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β spectrins are essential for the development of nervous system.
The spectrin-based membrane skeleton is essential to provide mechanical stability and membrane integrity. It is also responsible for protein organization, trafficking and resilience of erythrocytes.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Chanjae Lee et al.
Development genes and evolution, 219(6), 319-330 (2009-06-26)
One contributing factor in the worldwide decline in amphibian populations is thought to be the exposure of eggs to UV light. Enrichment of pigment in the animal hemisphere of eggs laid in the sunlight defends against UV damage, but little
A Choudhury et al.
Parasitology research, 83(8), 746-754 (1997-01-01)
Identification of neo-antigenic determinant(s) on parasite infected cell surface is important to control intracellular infections. Such determinant(s) on the surface of intact Plasmodium berghei infected erythrocytes have not been conclusively demonstrated. To generate polyclonal antiserum selectively recognizing the parasite infected
Different impacts of alleles alphaLEPRA and alphaLELY as assessed versus a novel, virtually null allele of the SPTA1 gene in trans
Delaunay J, et al.
British Journal of Haematology, 127(1), 118-122 (2004)
Spectrin and phospholipids - the current picture of their fascinating interplay.
Boguslawska DM, et al.
Cellular & Molecular Biology Letters, 19(1), 158-179 (2014)
Transgenic overexpression of caveolin-3 in skeletal muscle fibers induces a Duchenne-like muscular dystrophy phenotype
Galbiati F, et al.
Proceedings of the National Academy of Sciences of the USA, 97(17), 9689-9694 (2000)
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