推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
SOX2-6, monoclonal
表单
buffered aqueous solution
分子量
antigen ~35 kDa
种属反应性
human, mouse
浓度
~1.0 mg/mL
技术
western blot: 0.5-1.0 μg/mL using whole extract of human NT2 cells
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SOX2(6657)
mouse ... Sox2(20674)
rat ... Sox2(499593)
一般描述
Monoclonal Anti-SOX2 (mouse IgG1 isotype) is derived from the hybridoma SOX2-6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
SOX2 (sex-determining region Y-box 2) is a transcription factor that is made of 317 amino acid. It has a HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.
应用
Anti-Sox2 antibody has been used in western blotting and immunohistochemistry.
生化/生理作用
Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects the breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
CIBZ Regulates Mesodermal and Cardiac Differentiation of by Suppressing T and Mesp1 Expression in Mouse Embryonic Stem Cells
Kotoku T, et al.
Scientific Reports, 6 (2016)
CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog
Nishii T, et al.
The Journal of Biological Chemistry, 287(15), 12417-12424 (2012)
Thais Fernanda de Almeida Galatro et al.
PloS one, 8(4), e61605-e61605 (2013-04-25)
Inhibitor of DNA Binding 4 (ID4) is a member of the helix-loop-helix ID family of transcription factors, mostly present in the central nervous system during embryonic development, that has been associated with TP53 mutation and activation of SOX2. Along with
Differential expression of ID4 and its association with TP53 mutation, SOX2, SOX4 and OCT-4 expression levels
Galatro TF, et al.
PLoS ONE, 8(4) (2013)
Mutations in SOX2 cause anophthalmia
Fantes J, et al.
Nature Genetics, 33(4), 462-462 (2003)
商品
Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation.
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