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Merck
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安全信息

S1384

Sigma-Aldrich

N-Succinyl-Ala-Ala-Val p-nitroanilide

elastase substrate

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About This Item

经验公式（希尔记法）:
C21H29N5O8
CAS号:
61043-47-8
分子量:
479.48
EC 号:
262-569-3
MDL编号:
MFCD00038473
UNSPSC代码:
12352204
PubChem化学物质编号:
24899476

方案

≥98% (TLC)

表单

powder

溶解性

1 N NH4OH: 50 mg/mL, clear, yellow

储存温度

2-8°C

SMILES字符串

CC(C)C(NC(=O)C(C)NC(=O)C(C)NC(=O)CCC(O)=O)C(=O)Nc1ccc(cc1)N(=O)=O

InChI

1S/C21H29N5O8/c1-11(2)18(21(32)24-14-5-7-15(8-6-14)26(33)34)25-20(31)13(4)23-19(30)12(3)22-16(27)9-10-17(28)29/h5-8,11-13,18H,9-10H2,1-4H3,(H,22,27)(H,23,30)(H,24,32)(H,25,31)(H,28,29)

InChI key

IFAOJWCXOQHSQT-UHFFFAOYSA-N

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

底物

Substrate for human and rat leukocyte elastases

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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分析证书(COA)

Lot/Batch Number
BCBS2944V
BCBJ2221V
BCBG9764V
1395470
1397465

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Rami A Al-Horani et al.
Molecules (Basel, Switzerland), 24(11) (2019-06-09)
Pentamidine is bis-oxybenzamidine-based antiprotozoal drug. The parenteral use of pentamidine appears to affect the processes of blood coagulation and/or fibrinolysis resulting in rare but potentially life-threatening blood clot formation. Pentamidine was also found to cause disseminated intravascular coagulation syndrome. To
H R Wenzel et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 361(9), 1413-1416 (1980-09-01)
A simple synthesis is described for 3-carboxypropionyl-Ala-Ala-Val-4-nitroanilide, a convenient and very specific substrate for human leukocyte elastase (Km = 1.0mM, kcat = 8.7 s-1). The substrate does not undergo appreciable spontaneous hydrolysis. It is not cleaved by trypsin or chymotrypsin
Stein, R.L.,
Journal of the American Chemical Society, 105, 5111-5111 (1983)
G D Virca et al.
European journal of biochemistry, 144(1), 1-9 (1984-10-01)
Rat is a likely test animal for determining the efficacy of proteinase inhibitor drugs directed toward human leukocyte elastase and cathepsin G. We therefore sought to assess and compare relevant properties of both human and rat leukocyte elastase and cathepsin
Apparao B Kummarapurugu et al.
American journal of respiratory cell and molecular biology, 64(2), 260-267 (2020-12-03)
Cystic fibrosis (CF) lung disease is marked by high concentrations of neutrophil elastase (NE) and DNA polymers; both factors contribute to airway disease. Although inhaled recombinant human dornase alfa reduces the frequency of CF pulmonary exacerbations, it also increases free

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