质量水平
检测方案
≥95% (HPLC)
形式
solid
mp
>300 °C
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
CC(O)=O.OC(=O)c1ccc2-c3nc4ccccc4n3C(=O)c5cccc1c25
InChI
1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18;1-2(3)4/h1-9H,(H,23,24);1H3,(H,3,4)
InChI key
WNRSTFUVBWNELX-UHFFFAOYSA-N
一般描述
STO-609可降低体内肝癌细胞的致瘤性。TO-609以剂量依赖性方式减少了离子霉素对AMP(单磷酸腺苷)激活的蛋白激酶(AMPK)的激活。
乙酸1:1加合物
应用
STO609已被用作小鼠MLL-AF9急性髓系细胞白血病 (AML) 细胞中的钙/钙钙调蛋白依赖性蛋白激酶的激酶(CAMKK)抑制剂。
生化/生理作用
选择性Ca2+/钙调蛋白依赖性蛋白激酶的激酶 (CaM-KK) 拮抗剂。分别抑制 Ki = 80 和 15 ng/mL 的 CamKKa 和 CaMKKb。不抑制下游 CaM 激酶(CaMKI 和 CaMKIV)。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
CAMKs support development of acute myeloid leukemia
Journal of Hematology & Oncology, 11(1), 30-30 (2018)
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells
Cell Metabolism, 2(1), 21-33 (2005)
The camKK2/camKIV relay is an essential regulator of hepatic cancer
Hepatology, 62(2), 505-520 (2015)
Toxicology, 421, 22-29 (2019-04-04)
Voltage-gated sodium channels (VGSCs) represent molecular targets for a number of potent neurotoxins that affect the ion permeation or gating kinetics. BmK NT1, an α-scorpion toxin purified from Buthus martensii Karch (BMK), induces excitatory neurotoxicity by activation of VGSCs with
Molecular and cellular biochemistry, 449(1-2), 219-226 (2018-04-21)
Autosomal dominant polycystic kidney disease (ADPKD) is a common heritable human disease. Recently, the role of repressed autophagy in ADPKD has drawn increasing attention. Here, we investigate the mechanism underlying the effect of Saikosaponin-d (SSd), a sarcoplasmic/endoplasmic reticulum Ca2+ ATPase
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