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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
2A7-A1, monoclonal
分子量
antigen 110 kDa
包含
0.05% sodium azide
种属反应性
guinea pig, human, canine, mouse, rat, rabbit
技术
immunoprecipitation (IP): suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ATP2A2(488)
mouse ... Atp2a2(11938)
rat ... Atp2a2(29693)
一般描述
SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) is also known as ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). It codes for SERCA2a and SERCA2b, that are expressed in all tissues. SERCA2a is highly expressed in heart. SERCa2 is located on human chromosome 12q24.1.
免疫原
canine cardiac sarcoplasmic reticulum vesicles
应用
Anti-SERCa2 ATPase antibody has been used in western blotting and immunocytochemistry.
生化/生理作用
Mutation of SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) or ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) causes Dyskeratosis follicularis. SERCA2a plays a major role in controlling cardiomyocyte Ca2+. ATP2A2 mutation may cause Darier disease (DD).
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Modulation of sarcoplasmic reticulum Ca(2+)-ATPase by chronic and acute exposure to peroxynitrite
Gutierrez-Martin Y, et al.
European Journal of Biochemistry, 271(13), 2647-2657 (2004)
[Analysis of ATP2A2 gene mutations in a pedigree and a sporadic case with Darier disease]
Zhao X, et al.
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 33(5), 641-644 (2016)
Humberto Muzi-Filho et al.
Physiological reports, 3(10) (2015-10-29)
Epidemiological and animal studies have shown that placental undernutrition impairs reproduction in adult offspring, but the underlying molecular mechanisms within the male genital tract remain unknown. Due to its special physiological characteristics in transport and the modulation of the environment
Daisuke Shimura et al.
American journal of physiology. Heart and circulatory physiology, 310(1), H92-103 (2015-11-01)
Sarcolipin (SLN) is a small proteolipid and a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPase. In heart tissue, SLN is exclusively expressed in the atrium. Previously, we inserted Cre recombinase into the endogenous SLN locus by homologous recombination and succeeded in generating
Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes
Revuelta-Lopez E, et al.
Journal of Molecular and Cellular Cardiology, 85, 25-36 (2015)
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