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About This Item
经验公式（希尔记法）:
C19H18N2O3S
CAS号:
分子量:
354.42
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
yellow
mp
134-135.5 °C
溶解性
DMSO: 19 mg/mL
储存温度
−20°C
SMILES字符串
CCOc1cc(cc(CSc2ccccc2)c1O)\C=C(/C#N)C(N)=O
InChI
1S/C19H18N2O3S/c1-2-24-17-10-13(8-14(11-20)19(21)23)9-15(18(17)22)12-25-16-6-4-3-5-7-16/h3-10,22H,2,12H2,1H3,(H2,21,23)/b14-8+
InChI key
YKLMGKWXBLSKPK-RIYZIHGNSA-N
生化/生理作用
Protein tyrosine kinase inhibitor (IC50 = 370 nM). Also inhibits HGF-induced MAP kinase activation in hepatocytes and inhibits phospholipase D activity in human neutrophils.
包装
Light sensitive and packaged under nitrogen.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
S V Smirnov et al.
Circulation research, 76(2), 310-316 (1995-02-01)
The whole-cell patch-clamp technique was used to characterize the effects of several tyrosine kinase inhibitors on the voltage-gated K+ current (IK) in rat and rabbit pulmonary artery cells. IK was blocked in a dose-dependent manner by genistein (20 to 100
Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs.
R Nakaike et al.
The American journal of physiology, 271(1 Pt 2), H296-H302 (1996-07-01)
The effects of sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, on the endothelial nitric oxide (NO) pathway were studied in vitro. Vanadate caused endothelium-dependent relaxations in isolated porcine coronary arteries, which were abolished by N omega-nitro-L-arginine methyl ester. The
T Yamawaki et al.
Journal of the American College of Cardiology, 32(3), 780-786 (1998-09-19)
This study was designed to examine whether or not intramural delivery of ST638 (a specific tyrosine kinase inhibitor) with biodegradable stent can suppress the restenotic changes of the coronary artery in vivo. Clinical and animal studies demonstrated that restenosis after
Andreas Vocks et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 13(3), 165-172 (2003-07-24)
Polymorphonuclear leukocytes (neutrophils) release a variety of toxic agents--proteins and reactive oxygen species (ROS)--that are used to inactivate foreign microorganisms in the non-specific immune response. This study was undertaken to compare intracellular signalling pathways that lead to the ROS production
K Takenaga
Invasion & metastasis, 16(2), 97-106 (1996-01-01)
Treatment of high-metastatic Lewis lung carcinoma A11 cells with sodium orthovanadate, a phosphotyrosine phosphatase inhibitor, resulted in a dose- and time-dependent suppression of cell spreading on various extracellular matrix components such as Matrigel, fibronectin, laminin and type IV collagen, while
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