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S1129

Sigma-Aldrich

琥珀酰辅酶A 钠盐

≥85%

别名:

Succinyl CoA sodium salt

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About This Item

经验公式（希尔记法）:
C25H40N7O19P3S
CAS号:
108347-97-3
分子量:
867.61
UNSPSC代码:
41106305
PubChem化学物质编号:
24899460
NACRES:
NA.51

质量水平

200

方案

≥85%

表单

powder

溶解性

water: 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

[Na+].[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC([O-])=O

InChI

1S/C25H40N7O19P3S/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-2/t13-,18-,19-,20?,24-/m1/s1

InChI key

VNOYUJKHFWYWIR-FZEDXVDRSA-L

相关类别

应用

琥珀酰辅酶A钠盐已用于：
  • 体外赖氨酸的非酶促琥珀酰化，
  • 用作重组大肠杆菌中的己二酸生物合成底物
  • 蛋白质琥珀酰化的异柠檬酸脱氢酶（ICDH）处理
  • 用作底物，研究酶，比如乙酸盐：琥珀酸辅酶A转移酶和5-氨基乙酰丙酸合成酶（ALA合成酶）的特异性和动力学。

生化/生理作用

琥珀酰辅酶A在柠檬酸循环中是中间体。 它通过α-酮戊二酸脱氢酶催化α-酮戊二酸脱羧。琥珀酰辅酶A也可在单链脂肪酸β-氧化过程中由丙酰辅酶A形成。琥珀酰辅酶A在血红素合成中作为前体。它还可以用于酮体氧化。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
0000405276
0000378387
0000395145
0000396692
0000394624

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Koen W A van Grinsven et al.
Molecular and biochemical parasitology, 164(1), 74-79 (2008-12-24)
Fasciola hepatica contains anaerobically functioning mitochondria that produce acetate and propionate, the main endproducts excreted by this parasite. The final reactions in the pathways leading to these endproducts are performed by acetate:succinate CoA-transferase (ASCT) and propionate:succinate CoA-transferase (PSCT), respectively. The
Marc Schürmann et al.
Acta crystallographica. Section D, Biological crystallography, 71(Pt 6), 1360-1372 (2015-06-10)
3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase (AcdDPN7; EC 3.13.1.4) was identified during investigation of the 3,3'-dithiodipropionic acid (DTDP) catabolic pathway in the betaproteobacterium Advenella mimigardefordensis strain DPN7(T). DTDP is an organic disulfide and a precursor for the synthesis of polythioesters (PTEs) in
Generation of succinyl-coenzyme A in photosynthetic bacteria
Beatty J T and Gest H
Archives of Microbiology, 129, 335-340 (1981)
Koen W A van Grinsven et al.
The Journal of biological chemistry, 283(3), 1411-1418 (2007-11-21)
Acetate:succinate CoA-transferases (ASCT) are acetate-producing enzymes in hydrogenosomes, anaerobically functioning mitochondria and in the aerobically functioning mitochondria of trypanosomatids. Although acetate is produced in the hydrogenosomes of a number of anaerobic microbial eukaryotes such as Trichomonas vaginalis, no acetate producing
Comprehensive analysis of the lysine succinylome and protein co-modifications in developing rice seeds
Meng X, et al.
Molecular and Cellular Proteomics, mcp-RA119 (2019)
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