SMILES string
[Na+].[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC([O-])=O
InChI
1S/C25H40N7O19P3S/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-2/t13-,18-,19-,20?,24-/m1/s1
InChI key
VNOYUJKHFWYWIR-FZEDXVDRSA-L
assay
≥85%
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Application
琥珀酰辅酶A钠盐已用于：
- 体外赖氨酸的非酶促琥珀酰化，
- 用作重组大肠杆菌中的己二酸生物合成底物
- 蛋白质琥珀酰化的异柠檬酸脱氢酶（ICDH）处理
- 用作底物，研究酶，比如乙酸盐：琥珀酸辅酶A转移酶和5-氨基乙酰丙酸合成酶（ALA合成酶）的特异性和动力学。
Biochem/physiol Actions
琥珀酰辅酶A在柠檬酸循环中是中间体。 它通过α-酮戊二酸脱氢酶催化α-酮戊二酸脱羧。琥珀酰辅酶A也可在单链脂肪酸β-氧化过程中由丙酰辅酶A形成。琥珀酰辅酶A在血红素合成中作为前体。它还可以用于酮体氧化。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Xing Liu et al.
The EMBO journal, 39(11), e103285-e103285 (2020-04-18)
RLR-mediated type I IFN production plays a pivotal role in innate antiviral immune responses, where the signaling adaptor MAVS is a critical determinant. Here, we show that MAVS is a physiological substrate of SIRT5. Moreover, MAVS is succinylated upon viral
Suzana Savvi et al.
Journal of bacteriology, 190(11), 3886-3895 (2008-04-01)
Mycobacterium tuberculosis is predicted to subsist on alternative carbon sources during persistence within the human host. Catabolism of odd- and branched-chain fatty acids, branched-chain amino acids, and cholesterol generates propionyl-coenzyme A (CoA) as a terminal, three-carbon (C(3)) product. Propionate constitutes
Gregory A Hunter et al.
Biochimica et biophysica acta, 1814(11), 1467-1473 (2011-01-11)
Pyridoxal-5'-phosphate (PLP) is an obligatory cofactor for the homodimeric mitochondrial enzyme 5-aminolevulinate synthase (ALAS), which controls metabolic flux into the porphyrin biosynthetic pathway in animals, fungi, and the α-subclass of proteobacteria. Recent work has provided an explanation for how this
Marc Schürmann et al.
Acta crystallographica. Section D, Biological crystallography, 71(Pt 6), 1360-1372 (2015-06-10)
3-Sulfinopropionyl-coenzyme A (3SP-CoA) desulfinase (AcdDPN7; EC 3.13.1.4) was identified during investigation of the 3,3'-dithiodipropionic acid (DTDP) catabolic pathway in the betaproteobacterium Advenella mimigardefordensis strain DPN7(T). DTDP is an organic disulfide and a precursor for the synthesis of polythioesters (PTEs) in
Koen W A van Grinsven et al.
The Journal of biological chemistry, 283(3), 1411-1418 (2007-11-21)
Acetate:succinate CoA-transferases (ASCT) are acetate-producing enzymes in hydrogenosomes, anaerobically functioning mitochondria and in the aerobically functioning mitochondria of trypanosomatids. Although acetate is produced in the hydrogenosomes of a number of anaerobic microbial eukaryotes such as Trichomonas vaginalis, no acetate producing
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持