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Merck
CN

S1129

Sigma-Aldrich

琥珀酰辅酶A 钠盐

≥85%

别名:

Succinyl CoA sodium salt

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About This Item

经验公式(希尔记法):
C25H40N7O19P3S
分子量:
867.61
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51

质量水平

检测方案

≥85%

形式

powder

溶解性

water: 50 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

[Na+].[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC([O-])=O

InChI

1S/C25H40N7O19P3S/c1-25(2,20(38)23(39)28-6-5-14(33)27-7-8-55-16(36)4-3-15(34)35)10-48-54(45,46)51-53(43,44)47-9-13-19(50-52(40,41)42)18(37)24(49-13)32-12-31-17-21(26)29-11-30-22(17)32/h11-13,18-20,24,37-38H,3-10H2,1-2H3,(H,27,33)(H,28,39)(H,34,35)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-2/t13-,18-,19-,20?,24-/m1/s1

InChI key

VNOYUJKHFWYWIR-FZEDXVDRSA-L

应用

琥珀酰辅酶A钠盐已用于:
  • 体外赖氨酸的非酶促琥珀酰化
  • 用作重组大肠杆菌中的己二酸生物合成底物
  • 蛋白质琥珀酰化的异柠檬酸脱氢酶(ICDH)处理
  • 用作底物,研究酶,比如乙酸盐:琥珀酸辅酶A转移酶和5-氨基乙酰丙酸合成酶(ALA合成酶)的特异性和动力学。

生化/生理作用

琥珀酰辅酶A在柠檬酸循环中是中间体。 它通过α-酮戊二酸脱氢酶催化α-酮戊二酸脱羧。琥珀酰辅酶A也可在单链脂肪酸β-氧化过程中由丙酰辅酶A形成。琥珀酰辅酶A在血红素合成中作为前体。它还可以用于酮体氧化。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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Suzana Savvi et al.
Journal of bacteriology, 190(11), 3886-3895 (2008-04-01)
Mycobacterium tuberculosis is predicted to subsist on alternative carbon sources during persistence within the human host. Catabolism of odd- and branched-chain fatty acids, branched-chain amino acids, and cholesterol generates propionyl-coenzyme A (CoA) as a terminal, three-carbon (C(3)) product. Propionate constitutes
Xing Liu et al.
The EMBO journal, 39(11), e103285-e103285 (2020-04-18)
RLR-mediated type I IFN production plays a pivotal role in innate antiviral immune responses, where the signaling adaptor MAVS is a critical determinant. Here, we show that MAVS is a physiological substrate of SIRT5. Moreover, MAVS is succinylated upon viral
Gregory A Hunter et al.
Biochimica et biophysica acta, 1814(11), 1467-1473 (2011-01-11)
Pyridoxal-5'-phosphate (PLP) is an obligatory cofactor for the homodimeric mitochondrial enzyme 5-aminolevulinate synthase (ALAS), which controls metabolic flux into the porphyrin biosynthetic pathway in animals, fungi, and the α-subclass of proteobacteria. Recent work has provided an explanation for how this
Comprehensive analysis of the lysine succinylome and protein co-modifications in developing rice seeds
Meng X, et al.
Molecular and Cellular Proteomics, mcp-RA119 (2019)
Koen W A van Grinsven et al.
The Journal of biological chemistry, 283(3), 1411-1418 (2007-11-21)
Acetate:succinate CoA-transferases (ASCT) are acetate-producing enzymes in hydrogenosomes, anaerobically functioning mitochondria and in the aerobically functioning mitochondria of trypanosomatids. Although acetate is produced in the hydrogenosomes of a number of anaerobic microbial eukaryotes such as Trichomonas vaginalis, no acetate producing

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