推荐产品
重组
expressed in E. coli
质量水平
方案
≥90% (SDS-PAGE)
表单
lyophilized powder
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... SNCA(6622)
一般描述
α-Synuclein定位于人染色体4q22.1。它是一种固有的无序蛋白，具有N端不完美重复序列（KTKEGV），对聚集至关重要的中央NAC和酸性富集的柔性C端区域。α-Synuclein存在于路易体（LBs）和路易神经突（LNs）中。
应用
α在活性氧（ROS）测量，免疫组织化学和成像研究之前，已将人-Synuclein A53T用于治疗中脑神经元并刺激小胶质细胞。
生化/生理作用
α-Synuclein（α-Syn）与Toll样受体2（TLR2）相互作用，介导白细胞介素-1β（IL-1β）合成。
α-突触核蛋白基因中的点突变A53T（Ala53-Thr）与家族性帕金森氏′病有关。 表达A53T人α-突触核蛋白但不表达野生型或A30P变体的小鼠会发展为成年发作的神经退行性疾病，并伴有进行性运动 功能障碍，导致死亡。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Yan Zhou et al.
Molecular neurodegeneration, 11, 28-28 (2016-04-17)
α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease (PD), has been recognized to induce the production of interleukin-1β in a process that depends, at least in vitro, on nod-like receptor protein 3 (NLRP3) inflammasome in monocytes. However, the role of
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53? Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
Lee MK, et al.
Proceedings of the National Academy of Sciences, 99(13), 8968-8973 (2002)
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function.
Ciaran P A Doherty et al.
Nature structural & molecular biology, 27(3), 249-259 (2020-03-12)
Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology. The central region of the αSyn sequence contains the non-amyloid β-component (NAC) crucial for aggregation. However, how NAC flanking regions modulate αSyn aggregation remains unclear. Using bioinformatics, mutation
Mehmet Ozansoy et al.
Molecular neurobiology, 47(2), 460-465 (2012-11-28)
Parkinson's disease (PD) is the second most common neurodegenerative disorder, defined by the presence of resting tremor, muscular rigidity, bradykinesia, and postural instability. PD is characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta of
Nathan Meyer et al.
ACS central science, 8(4), 441-448 (2022-05-05)
The detection to α-synuclein (αS) assemblies as a biomarker of synucleinopathies is an important challenge for further development of an early diagnosis tool. Here, we present proof of concept real-time fast amyloid seeding and translocation (RT-FAST) based on a nanopipette
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门