硫化物 来源于牛大脑

硫苷脂是主要由半乳脑神经苷硫酸盐组成的 3-O-磺基半乳糖基神经酰胺。它位于髓鞘中，约占脑中总髓磷脂的 4％。

Sulfatideis a glycospingolipid and plays an essential role in host-pathogen recognition,β-cell function, infection, haemostasis/thrombosis, protein trafficking, cellgrowth, cell adhesion, neuronal plasticity, cell morphogenesis, and signaltransduction. It is found on the surface of the blood cells such asplatelets, leukocytes, and erythrocytes. Sulfatides are also found in the serumas glycosphingolipids in lipoproteins. It is made up of glycan part, a hydrophobic part, 3-O-sulfated galactose, and ceramide, which in turn is composed of a sphingosine base and a fatty acid. It is an important component forthe maintenance of the myelin sheath andproper formation of the axo-glial junctions. Variations in the production ofsulfatides are associated with various human diseases like cancer andimmunological disorders. Alterations in the sulfatide metabolism lead to synapticdysfunction, neurological decline, inflammation, and myelin deterioration.

硫化物已用于：

• 人体血浆样品中的酶联免疫吸附测定（ELISA）
• 髓磷脂膜上的薄层色谱
• 备解素的硫酸盐结合试验

硫苷脂在神经系统、免疫系统和胰岛素分泌的生理过程中起关键作用。溶酶体中硫苷脂分解代谢的异常与晚期婴儿异染性脑白质营养不良有关。在卵巢癌中也观察到高水平的硫苷脂。硫苷脂参与中枢神经系统慢性炎症性疾病的发病机理。