S0758
磺胺苯吡唑
≥98%, CYP2C9 inhibitor, powder
别名:
4-氨基-N-(1-苯基-1H-吡唑-5-基)苯磺酰胺
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关于此项目
经验公式（希尔记法）:
C15H14N4O2S
化学文摘社编号:
分子量:
314.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
208-384-3
MDL number:
产品名称
磺胺苯吡唑, ≥98%
InChI key
QWCJHSGMANYXCW-UHFFFAOYSA-N
InChI
1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3
assay
≥98%
form
powder
solubility
ethanol: 25 mg/mL, clear, colorless to yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... CYP2C18(1562), CYP2C19(1557), CYP2C9(1559)
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Application
磺胺苯吡唑已用作定量分析红景天提取物对细胞色素P450 2C9(cyp2c9)抑制作用的阳性对照。也用作内皮细胞和微粒体制品中的细胞色素P450 2C9 (cyp2c9)抑制剂。
Biochem/physiol Actions
抗细菌。CYP2C9的特异性抑制剂。阻断由CYP2C9介导的亚油酸（氧化应激和AP-1活化增加）的促炎症和致动脉粥样硬化作用。CYP2C9的特异性抑制剂。阻断由CYP2C9介导的亚油酸（氧化应激和AP-1活化增加）的促炎症和致动脉粥样硬化作用。抑制缓激肽诱导的tPA释放。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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