Spectinomycin

Chemical structure: aminoglycoside

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

作用方式：通过干扰肽基 tRNA 的转位抑制蛋白质合成（延伸）。
抗菌谱：革兰氏阴性和革兰氏阳性菌（仅包括淋球菌）。
抗性机理：rpsE（核糖体蛋白 S5 的基因）的突变可阻止壮观霉素的结合。

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

Stock solutions should be prepared at 10 mg/mL in water and 0.2 μm filtered.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Store under inert gas.

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas