推荐产品
生物来源
Streptomyces sp.
质量水平
形式
solution
储存条件
(Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Store under inert gas.)
浓度
100 mg/mL in DMSO/H2O, 1:1
颜色
colorless
溶解性
DMSO/H2O, 1:1: soluble 100 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
作用机制
protein synthesis | interferes
运输
wet ice
储存温度
−20°C
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一般描述
Chemical structure: aminoglycoside
应用
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.
生化/生理作用
作用方式：通过干扰肽基 tRNA 的转位抑制蛋白质合成（延伸）。
抗菌谱：革兰氏阴性和革兰氏阳性菌（仅包括淋球菌）。
抗性机理：rpsE（核糖体蛋白 S5 的基因）的突变可阻止壮观霉素的结合。
抗菌谱：革兰氏阴性和革兰氏阳性菌（仅包括淋球菌）。
抗性机理：rpsE（核糖体蛋白 S5 的基因）的突变可阻止壮观霉素的结合。
注意
Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
制备说明
Stock solutions should be prepared at 10 mg/mL in water and 0.2 μm filtered.
储存及稳定性
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Store under inert gas.
其他说明
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas
WGK
WGK 2
闪点(°F)
201.0 °F
闪点(°C)
93.9 °C
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Holloway, W.J.
Med. Clin. North Amer., 66, 169-173 (1982)
Ausubel, F.M., et al.
Current Protocols in Molecular Biology, 1-1 (1987)
A P Carter et al.
Nature, 407(6802), 340-348 (2000-10-03)
The 30S ribosomal subunit has two primary functions in protein synthesis. It discriminates against aminoacyl transfer RNAs that do not match the codon of messenger RNA, thereby ensuring accuracy in translation of the genetic message in a process called decoding.
C Y Chang et al.
The Journal of antimicrobial chemotherapy, 46(1), 87-89 (2000-07-07)
Two new gene cassettes, dfr17 and aadA4, inserted in a class 1 integron of Escherichia coli EC107, are described here. The dfr17 cassette encodes trimethoprim resistance and has 91% identity with the dfrVII dihydrofolate reductase gene. The aadA4 cassette confers
Sambrook, J., et al.
Molecular Cloning: A Laboratory Manual, 1-1 (1989)
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