生物来源
bacterial (Streptococcus sp.)
质量水平
重组
expressed in E. coli
检测方案
40—60% protein (biuret)
形式
lyophilized solid
比活
≥3,500 unit/mg solid
颜色
off-white to light yellow
应用
life science and biopharma
储存温度
−20°C
基因信息
Streptococcus pyogenes ... SKC(134997)
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一般描述
Research area: Cell Signaling
Streptokinase is an extracellular enzyme, a single-chain polypeptide produced by several strains of β-hemolytic Streptococci. It is composed of multiple structural domains like α-, β-, and γ-domains that are involved in various functions.
Streptokinase is an extracellular enzyme, a single-chain polypeptide produced by several strains of β-hemolytic Streptococci. It is composed of multiple structural domains like α-, β-, and γ-domains that are involved in various functions.
应用
Streptokinase C from Streptococcus sp. has been used to quantitate the survival of Staphylococcus aureus in whole human blood.
生化/生理作用
Streptokinase shows fibrinolytic activity by triggering the circulatory plasminogen either via a fibrin-dependent or fibrin-independent mechanism. Streptokinase has been studied majorly in terms of its therapeutic efficacy and treating myocardial infarction to dissolve clots.
单位定义
One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.
外形
Lyophilized powder containing approx. 50% bovine serum albumin (total protein by biuret) with sodium glutamate.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Kerstin Steiner et al.
Infection and immunity, 70(7), 3627-3636 (2002-06-18)
Synthesis of the plasminogen activator streptokinase (SK) by group A streptococci (GAS) has recently been shown to be subject to control by two two-component regulators, covRS (or csrRS) and fasBCA. In independent studies, response regulator CovR proved to act as
Streptokinase production from Streptococcus dysgalactiae subsp. equisimilis SK-6 in the presence of surfactants, growth factors and trace elements
Bhardwaj S and Angayarkann J
3 Biotech, 5(2), 187?193-187?193 (2015)
Jakub M Kwiecinski et al.
Cell reports, 36(4), 109462-109462 (2021-07-29)
Skin is one of the most common sites of host immune response against Staphylococcus aureus infection. Here, through a combination of in vitro assays, mouse models, and intravital imaging, we find that S. aureus immune evasion in skin is controlled by a
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