S0532
番木鳖碱
Glycine receptor antagonist
别名:
(-)-番木鳖碱
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关于此项目
经验公式（希尔记法）:
C21H22N2O2
化学文摘社编号:
分子量:
334.41
NACRES:
NA.54
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
200-319-7
MDL number:
Beilstein/REAXYS Number:
52979
产品名称
番木鳖碱,
InChI key
QMGVPVSNSZLJIA-FVWCLLPLSA-N
InChI
1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1
SMILES string
[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]
mp
284-286 °C (lit.)
solubility
chloroform: soluble, clear to hazy
Quality Level
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Biochem/physiol Actions
惊厥剂；与 NMDA 受体无关的甘氨酸受体拮抗剂。
At low doses, strychnine is used for circulatory problems, gastrointestinal disorders and eye diseases.
Strychnine is used as a rodenticide and a glycine receptor antagonist, which inhibits Renshaw cell-motor neuron synapse. It binds to the α subunit N-terminal region of the glycine receptor. The effect of strychnine is neutralized in the presence of glycine receptor agonist ivermectin. Strychnine also inhibits leukocyte motility.
Application
Strychnine has been used as a glycine receptors antagonist in hippocampal CA1 pyramidal and rostral ventromedial medulla (RVM) neurons. It has also been used as type C glycine receptor antagonist in direction selective (DS) retinal cells.
Strychnine has been used in antagonist profiling to characterize a novel nicotinic receptor in Aplysia neuroendocrine cells.
General description
Strychnine is a colorless, odourless and bitter tasting powder. It is absorbed in skin, gastrointestinaland respiratory tract. Strychnine generates oxides of nitrogen and carbon on decomposition.
Strychnine is a glycine receptor antagonist not associated with the N-methyl-D-aspartate (NMDA) receptor. It is an alkaloid extracted from Strychnos nux vomica seeds.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
涉药品监管产品
此项目有
A brainstem-spinal cord inhibitory circuit for mechanical pain modulation by GABA and enkephalins
Franccois A, et al.
Neuron, 93(4), 822-839 (2017)
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient
Woo J, et al.
Experimental Neurobiology, 28(1), 30-42 (2019)
Glycine-gated chloride channels in neutrophils attenuate calcium influx and superoxide production
WHEELER M, et al.
Faseb Journal, 14(3), 476-484 (2000)
In vivo protection against strychnine toxicity in mice by the glycine receptor agonist ivermectin
Maher A, et al.
BioMed Research International (2014)
Spatiotemporally asymmetric excitation supports mammalian retinal motion sensitivity
Matsumoto A, et al.
Current Biology, 29(19) (2019)
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