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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
yellow
溶解性
H2O: <2 mg/mL
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35
InChI
1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChI key
CDKIEBFIMCSCBB-CALJPSDSSA-N
应用
Sugar insensitive 3 (SIS3) 已被用作各种细胞中的samd3抑制剂。
生化/生理作用
SIS3 是一种 TGF-β1/ALK-5磷酸化 Smad3 的新型特异性抑制剂
Sugar insensitive 3 (SIS3) 促进药物引起的细胞凋亡,并阻碍三磷酸腺苷(ATP)结合盒(ABC)转运蛋白 (ABCB1) 和ABCG2发挥功能。它使在癌细胞中过度表达的ABCB1 和 ABCG2再次敏化,这有助于化疗。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells
Experimental Eye Research, 93(4), 442-451 (2011)
Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes?But without modulating bone morphogenetic protein 7 signaling
Hepatology, 49(6), 2021-2030 (2009)
The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring
Kidney International, 93(1), 173-187 (2018)
Cancer science, 110(8), 2507-2519 (2019-06-20)
Abnormal tumor microenvironment and the epithelial-mesenchymal transition (EMT) are important features of tumor metastasis. However, it remains unknown how signals can form complicated networks to regulate the sustainability of the EMT process. The aim of our study is to explore
American journal of rhinology & allergy, 30(6), 385-390 (2017-01-27)
It is well known that doxycycline has antibacterial and anti-inflammatory effects. In this study, we aimed to investigate the effects of doxycycline on the transforming growth factor (TGF) beta 1-induced matrix metalloproteinase (MMP) 2 expression, migration, and collagen contraction, and
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