所有图片(1)
别名:
(2E)-1-(6,7-二甲氧基-3,4-二氢-1H-异喹啉-2-基)-3-(1-甲基-2-苯基-1H-吡咯并[2,3-b]吡啶吡啶-3-基)-丙烯酮 盐酸盐
经验公式（希尔记法）:
C28H27N3O3 · HCl
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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
yellow
溶解性
H2O: <2 mg/mL
DMSO: >20 mg/mL
储存温度
2-8°C
SMILES字符串
Cl.COc1cc2CCN(Cc2cc1OC)C(=O)\C=C\c3c(-c4ccccc4)n(C)c5ncccc35
InChI
1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChI key
CDKIEBFIMCSCBB-CALJPSDSSA-N
应用
Sugar insensitive 3 (SIS3) 已被用作各种细胞中的samd3抑制剂。
生化/生理作用
Sugar insensitive 3 (SIS3) 促进药物引起的细胞凋亡，并阻碍三磷酸腺苷（ATP）结合盒（ABC）转运蛋白 (ABCB1) 和ABCG2发挥功能。它使在癌细胞中过度表达的ABCB1 和 ABCG2再次敏化，这有助于化疗。
SIS3 是一种 TGF-β1/ALK-5磷酸化 Smad3 的新型特异性抑制剂
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Ming-Heng Wu et al.
Scientific reports, 7(1), 11006-11006 (2017-09-10)
Concomitant expressions of glycan-binding proteins and their bound glycans regulate many pathophysiologic processes, but this issue has not been addressed in liver fibrosis. Activation of hepatic stellate cells (HSCs) is a rate-limiting step in liver fibrosis and is an important
SIS3, a specific inhibitor of Smad3 reverses ABCB1-and ABCG2-mediated multidrug resistance in cancer cell lines
Wu CP, et al.
Cancer letters, 433, 259-272 (2018)
Karl David Brown et al.
Investigative ophthalmology & visual science, 58(7), 3011-3017 (2017-06-13)
Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase-derived reactive oxygen species has been
Jae-Min Shin et al.
American journal of rhinology & allergy, 30(6), 385-390 (2017-01-27)
It is well known that doxycycline has antibacterial and anti-inflammatory effects. In this study, we aimed to investigate the effects of doxycycline on the transforming growth factor (TGF) beta 1-induced matrix metalloproteinase (MMP) 2 expression, migration, and collagen contraction, and
Benjamin V Park et al.
Cancer discovery, 6(12), 1366-1381 (2016-09-30)
Programmed death-1 (PD-1) is a coinhibitory receptor that downregulates the activity of tumor-infiltrating lymphocytes (TIL) in cancer and of virus-specific T cells in chronic infection. The molecular mechanisms driving high PD-1 expression on TILs have not been fully investigated. We
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